To explore the characteristics of comorbidities and polypharmacy inpatients with Parkinson's disease(PD)based on immunoinflammatory indexes
Objective Based on the comprehensive analysis of immune inflammation indicators,the charac-teristics of comorbidities and combination therapy in Parkinson's disease(PD)patients are analyzed,pro-viding clinical basis for further guidance and optimization of treatment plans for PD patients.Methods A total of 527 PD patients admitted to the Xinjiang Clinical Research Center for Neurological Diseases from October 2020 to March 2023 were selected as the study group.A total of 526 healthy individuals who un-derwent physical examinations during the same period were randomly selected as the control group.The age,gender,platelet(PLT),neutrophil(N),lymphoid cell(LYM)counts,as well as the distribution characteristics of comorbidities and combination therapy in PD patients were compared and analyzed.Fur-ther subgroup analysis was conducted on the Systemic Immune Inflammation Index(SII)and Neutrophil/Lymphocyte Count Ratio(NLR).Results Compared with the control group,the N level,SII,and NLR in the study group was increased,while PLT and LYM was decreased,and the differences were statistical-ly significant(P＜0.05).The maximum number of comorbidities among PD patients was 8,and the max-imum number of combined medication varieties was 23.As the patient ages,both the number of comor-bidities and the variety of medications wereincreased(P=0.000).There was a weak correlation between the number of comorbidities and the number of medication types in PD patients(Cramer's V=0.296,P＜0.001).Subgroup analysis showed that the number of comorbidities and types of medication in PD patients who used neurotrophic drugs,laxatives and second-class psychotropic drugs for a long time were in-creased,and the difference was statistically significant(P＜0.05).Compared with PD patients who do not require long-term use of nutritional nerve drugs,PD patients who require long-term use of nutritional nerve drugs account for 53.42％of the total number of patients.SII,NLR and N wasincreased,while LYM and PLT wasdecreased,and the difference was not statistically significant(P＞0.05).Compared with PD patients who do not require long-term use of second-class psychotropic drugs,PD patients who re-quired long-term use of second-class psychotropic drugs account for 30.61％of the total number of thepa-tients,with a decrease in N and an increase in PLT,and the differences were statistically significant(P＜0.05).Compared with PD patients who did not require long-term use of laxatives,PD patients who re-quired long-term use of laxatives account for 30.61％of the total number of the patients,with a decrease in LYM and PLT,and the difference was statistically significant(P＜0.05).Conclusion In the diagnosis and treatment of PD,attention should be paid to the patient's age,blood cell inflammatory factor count and immune inflammatory index,which has clinical value for early optimization of peripheral nerve nutri-tion,regulation of comorbidities such as constipation and sleep,and combination therapy in PD patients.
万方数据
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