Analysis of medication and acupoint selection rules for polycystic ovary syndrome infertility based on data mining
Objective The data mining method was applied to summarise the rules of traditional Chinese medicine(TCM)formulas and acupuncture points for the treatment of infertility in polycystic ovary syn-drome,so as to provide a reference for the future clinical prescription and use of medicines.Methods Medical cases of TCM interventions for PCOS infertility included in China Knowledge Network database from es-tablishment of the database to 14 June 2023 were collected.Excel was used to establish the database and enter into the ancient and modern medical cases cloud platform(V2.2.3),and data mining was carried out through TCM and acupuncture on TCM evidence frequency analysis,drug pair analysis,association rule analysis,cluster analysisand complex network analysis.Results Finally,205 studies were included,with 163 RCTs and 42 clinical experiences,each accounting for 79.5％and 20.5％.There were 146 TCM syn-dromes of PCOS infertility,with 292 flavours of traditional chinese medicines(TCMs),and the total number of medication frequencies was 4 091,and a total of 72 acupoints were included for a total of 301 frequencies.The top 4 flavours of TCM symptoms from high to low were renal deficiency and blood stasis,renal essence deficiency,renal yang deficiency and renal deficiency and liver depression,the top 2 patho-logical elements were deficiency and qi depression,and the top 2 pathological elements were kidney and liver;the top 5 high-frequency single drugs in terms of frequency of TCM were semen cuscutae,angelica,cyperus rotundus,prepared rehmannia root and poria;the four qualities of qi were dominated by warmth and flatness,the five flavours were dominated by sweetness and acridity,and most of the medicines were attributed to the three meridians,namely,the liver,the spleen,and the kidney.The top 3 TCM efficacies were strengthening the bones and muscles,regulating menstruation and relieving pain,and tonifying the liver and kidneys;the cluster analysis of TCM yielded 9 cluster combinations;the association rule analysis yielded 13 association rules;and the top 3 acupoint frequencies were related to Guanyuan,Sanyinjiao,and the uterus;the core prescription was"Guanyuan-Zhongji-Uterus-Sanyinjiao-Zusanli-Qihai".Complex net-work analysis showed that Guanyuan,Sanyinjiao and semen cuscutae was the most closely related points.Guanyuan was often used together with cyperus rotundus,poria,pinellia ternata,lycii fructus,prepared rehmannia root and rhizoma dioscoreae.Sanyinjiao was often used together with corni fructus,angelica,semen cuscutae,prepared rehmannia root,lycii fructusand rhizoma dioscoreae.Semen cuscutae was often used together with Guanyuan,Qihai,Zhongji,Zusanli and Sanyinjiao.Conclusion Modern Chinese medi-cine treatment of PCOS infertility to tonify the liver and kidney,regulate menstruation and relieve pain,strengthen the tendons and bones as the main treatment,clinical acupuncture points focus on the surface and inside the same treatment,the upper and lower the same adjustment.
polycystic ovary syndrome infertilityancient and modern medical case cloud platformdata miningmedication patternacupuncture point pattern
万方数据
维普
