Objective Observing the effects of Qufeng Zhijing San on extracellular signal regulated pro-tein kinase-1,ERK-2,matrix metalloproteinase-9,IL-6,IL-8,and IL-13 in patients with bronchial asth-ma(asthma wind phlegm asthma syndrome).The effects of Interleukin-17(IL-17),Interleukin-32(IL-32)and serum Orosmucoid1-like protein 3(ORMDL3)genes on asthma airway inflammation were investi-gated,and the mechanism of Qufeng Zhijing San in improving asthma airway inflammation was explored.Methods 75 patients diagnosed with bronchial asthma(asthma wind phlegm asthma syndrome)who visi-ted to the hospital from July 2021 to May 2022 were randomly divided into a control group(n=38)and an experimental group(n=37)using a random number table method.Simultaneously select individuals who underwent health examinations during the same period as health group(n=10).The control group was given budesonide fumoterol powder inhaler(160/4.5μg)twice a day,with one inhaler per session.The experimental group was orally administered in combination with traditional Chinese medicine(TCM)Qufeng Zhijing San on the basis of the control group.The treatment period was 3 months.The health group will not receive treatment.Polymerase chain reaction(PCR)and enzyme-linked immunosorbent as-say(ELISA)were used to detect and compare the differences in ERK-1,ERK-2,ORMDL-3,MMP-9,IL-6,IL-8,IL-13,IL-17 and IL-32 levels among the 3 groups before and after the medication.Results Before the treatment,compared with the healthy group,the levels of ORMDL-3,ERK-2 and ERK-1 in the control group and experimental group were significantly increased,with statistical significance(P＜0.05);Com-pared with the healthy group,there was no statistically significant difference in MMP-9 expression levels between control group and experimental group(P＞0.05).Compared with control group,there was no statistically significant difference in the expression levels of ORMDL-3,ERK-2,ERK-1 and MMP-9 in the experimental group(P＞0.05).After the treatment,there was no statistically significant difference be-tween experimental group and control group in IL-6,IL-8,IL-17,IL-32,ERK-1 and ORMDL-3(P＞0.05),but the levels of IL-13 and ERK-2 in the experimental group were significantly lower than those in the control group,and the difference was statistically significant(P＜0.05).Conclusion Qufeng Zhijing San may alleviate the inflammatory response mediated by patients with bronchial asthma(asthma wind phlegm asthma syndrome)by reducing the expression level of ERK-2 and IL-13.
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