Effect of Qufeng Zhijing San on airway inflammation and airway remodelling in patients with bronchial asthma(asthma wind phlegm asthma syndrome)
Objective Observing the effects of Qufeng Zhijing San on extracellular signal regulated pro-tein kinase-1,ERK-2,matrix metalloproteinase-9,IL-6,IL-8,and IL-13 in patients with bronchial asth-ma(asthma wind phlegm asthma syndrome).The effects of Interleukin-17(IL-17),Interleukin-32(IL-32)and serum Orosmucoid1-like protein 3(ORMDL3)genes on asthma airway inflammation were investi-gated,and the mechanism of Qufeng Zhijing San in improving asthma airway inflammation was explored.Methods 75 patients diagnosed with bronchial asthma(asthma wind phlegm asthma syndrome)who visi-ted to the hospital from July 2021 to May 2022 were randomly divided into a control group(n=38)and an experimental group(n=37)using a random number table method.Simultaneously select individuals who underwent health examinations during the same period as health group(n=10).The control group was given budesonide fumoterol powder inhaler(160/4.5μg)twice a day,with one inhaler per session.The experimental group was orally administered in combination with traditional Chinese medicine(TCM)Qufeng Zhijing San on the basis of the control group.The treatment period was 3 months.The health group will not receive treatment.Polymerase chain reaction(PCR)and enzyme-linked immunosorbent as-say(ELISA)were used to detect and compare the differences in ERK-1,ERK-2,ORMDL-3,MMP-9,IL-6,IL-8,IL-13,IL-17 and IL-32 levels among the 3 groups before and after the medication.Results Before the treatment,compared with the healthy group,the levels of ORMDL-3,ERK-2 and ERK-1 in the control group and experimental group were significantly increased,with statistical significance(P＜0.05);Com-pared with the healthy group,there was no statistically significant difference in MMP-9 expression levels between control group and experimental group(P＞0.05).Compared with control group,there was no statistically significant difference in the expression levels of ORMDL-3,ERK-2,ERK-1 and MMP-9 in the experimental group(P＞0.05).After the treatment,there was no statistically significant difference be-tween experimental group and control group in IL-6,IL-8,IL-17,IL-32,ERK-1 and ORMDL-3(P＞0.05),but the levels of IL-13 and ERK-2 in the experimental group were significantly lower than those in the control group,and the difference was statistically significant(P＜0.05).Conclusion Qufeng Zhijing San may alleviate the inflammatory response mediated by patients with bronchial asthma(asthma wind phlegm asthma syndrome)by reducing the expression level of ERK-2 and IL-13.
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