Correlation analysis of systemic immune inflammatory index and immunoglobulin levels with exercise complications in Parkinson's disease(PD)patients
Objective To investigate the association of systemic immune inflammatory index and immuno-globulin levels with exercise complications in Parkinson's disease(PD)patients.Methods 218 PD patients diagnosed in the hospital from January 2022 to June 2023 were selected as study subjects.The patients were divided into the group with motor complications and the group without motor complications based on whether their clinical symptoms fluctuated and whether they had dyskinesia.The general data of the 2 groups were collected.The neutrophil lymphocyte ratio(NLR)and systemic immune-inflammation index(SII)were measured by SYSMEX XN-3000 automatic analyzer.The A-albumin and α1,α2,β,γ immuno-globulins in 2 groups were detected by Beckmann's special protein analyzer.Results NLR,SII and γ-globulin were higher and A-albumin was lower in the group with exercise complications than in the group without exercise complications(P＜0.05).Logistic regression analysis showed that SII,A-albumin,γ-globulin and H-Y staging were the risk factors of PD motor complications(P＜0.05).ROC showed that AUC of SII,A-albumin,γ-globulin and H-Y staging were 0.752,0.643,0.704,0.746 and 95％CI were 0.683-0.822,0.549-0.737,0.619-0.788 and 0.670-0.823.The AUC of combined detection was 0.858,with a 95％CI of 0.796 to 0.920.Conclusion High levels of SII,γ-globulin,H-Y staging and low A-albumin increase the risk of motor complications in PD.
万方数据
维普
