Study on early warning effect of interaction between urinary PSA and other risk factors on prostatic hyperplasia in elderly patients
Objective Analysis of the interaction between urinary prostate specific antigen(PSA)and other risk factors on prostatic hyperplasia in elderly patients.Methods From May 2021,97 elderly patients with prostatic hyperplasia admitted in May 2023 were selected as study group,and 84 normal elderly pa-tients were selected as control group.The oxidative stress markers,urinary PSA and serum PSA levels in the 2 groups were detected,and the risk factors of elderly prostatic hyperplasia and the interaction between urinary PSA and risk factors were analyzed.Results Compared with control group,the study patients had decreased expression levels of superoxide dismutase(SOD),antioxidant status(TAS),and increased uri-nary PSA,serum PSA and malondialdehyde(MDA)(P＜0.05).Univariate analysis showed that the oc-currence of prostatic hyperplasia in the elderly was unrelated to age,hyperlipidemia,growth factors,his-tory of gross hematuria and urinary tract infection(P＞0.05),and obesity,abnormal detrusor function,hypertension,diabetes,androgens,bladder neck fibrosis,diet and inflammation(P＜0.05).With senile prostatic hyperplasia as the dependent variable(no occurrence=0;occurrence=1),multivariate Logistics regression analysis,the results showed that obesity 28 kg/m2,abnormal detrusor function,hypertension,androgen,diabetes,bladder neck fibrosis,diet,inflammation,urinary PSA and serum PSA were risk fac-tors affecting prostatic hyperplasia in the elderly(P＜0.05).Analyzing the effect of the interaction be-tween urinary PSA and other risk factors on prostatic hyperplasia in elderly patients,the results showed that there was a product interaction between urinary PSA and depressive symptoms on prostatic hyperpla-sia in elderly patients(P＜0.05).Conclusion The interaction between urinary PSA and risk factors have an early warning effect on prostatic hyperplasia in the elderly.
prostatic hyperplasia in the elderlyurinary prostate-specific antigeninteractionrisk factorsearly warning
万方数据
维普
