Correlation between visceral adipose tissue(VAT)metabolism and lymph nodes met metastasis in patients with endometrial cancer
Objective To study the correlation between visceral adipose tissue(VAT)metabolism and lymph node metastasis in patients with endometrial cancer.Methods 116 patients with endometrial cancer admitted to the hospital from June 2017 to December 2022 were selected as study subjects.Prior to surger-y,the patients underwent 18F-FDG PET/CT examination and were divided into lymph node metastasis group and lymph node non-metastasis group based on their lymph node metastasis status.The maximum standard uptake value(SUVmax)of VAT,the SUVmax of subcutaneous adipose tissue(SAT),the SU-Vmax of spleen and the SUVmax of bone marrow(BM)of the 2 groups of the patients were measured on PET/CT images(between L4 and L5 vertebral levels).The metabolic activity of VAT was defined as V/S ratio,which was the ratio of the SUVmax of VAT to the SUVmax of SAT.The correlation between VAT metabolic activity and lymph node metastasis was analyzed.Results Compared with the non-meta-static lymph node group,the V/S ratio,the SUVmax of spleen,and the SUVmax of BM in the metastatic lymph node group was significantly increased,and there was a significant correlation with V/S values.The results of multivariate Logistic regression analysis showed that the V/S ratio was independently corre-lated with lymph node metastasis.Conclusion The metabolic activity of VAT(V/S ratio)was independ-ently associated with lymph node metastasis in endometrial cancer patients,and VAT can serve as a poten-tial marker for obesity induced inflammation and lymph node metastasis in endometrial cancer.