Objective To investigate the effects of thoracoscopic single-hole and multi-hole segmental pneu-monectomy on metabolic response and cardiopulmonary tolerance in patients with early non-small cell lung cancer(NSCLC).Methods 92 patients with early NSCLC in the hospital from June 2017 to October 2022 were selected and divided into porous group and single pore group according to simple random number ta-ble,with 46 patients in each group.Thoracoscopic single-hole segmental pneumonectomy was performed in the single-hole group,and thoracoscopic multi-hole segmental pneumonectomy was performed in the multi-hole group.The perioperative conditions,preoperative and postoperative 3 d metabolic response in-dexes(retinol-binding protein(RBP),transferrin(TRF),prealbumin(PA)and cardiorespiratory endur-ance of 2 groups were analyzed 6 min walking distance(6MWT),fatigue index,peak expiratory flow rate(PEF),forced expiratory volume in the first second(FEV1)and complication rate.Results(1)There were no statistically significant differences in operation duration and number of lymph node dissection be-tween the 2 groups(P＞0.05).The intraoperative blood loss and drainage volume in the single-hole group was less than those in the porous group,and the placement time of drainage tube and length of hospitaliza-tion were significantly different than those in the porous group(P＜0.05).(2)The levels of PA,TRF and RBP in the 2 groups were lower than those before surgery 3 days after operation,but the levels of PA,TRF and RBP in the single-hole group were higher than those in the multi-hole group,and the difference was statistically significant(P＜0.05).(3)At 3 days after operation,6MWT,PEF and FEV1 in both groups were lower than before operation,and fatigue index was higher than before operation,but 6MWT,PEF and FEV1 in the single-well group were higher than those in the multi-hole group,and fatigue index was lower than those in the multi-hole group,with statistical significance(P＜0.05).(4)The incidence of complications in the single-pore group(4.35％)was lower than that in the multi-pore group(17.39％),and the difference was statistically significant(P＜0.05).Conclusion Thoracoscopic single-hole and multi-hole segmental pneumonectomy can achieve good results in the treatment of early NSCLC,but sin-gle-hole surgery can reduce blood loss,have little impact on metabolic status and cardiopulmonary endur-ance,facilitate the early recovery of body function,and reduce the risk of complications.
维普
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