Predictive value of Essen stroke risk score combined with oxidized low-density lipoprotein(OX-LDL)and ubiquitin C-terminal hydrolase(UCH-L1)in short-term prognosis of patients with first acute ischemic stroke in non-atrial fibrillation population
Objective To investigate the predictive value of Essen stroke risk score combined with oxidized low-density lipoprotein(OX-LDL)and serum ubiquitin C-terminal hydrolase L1(UCH-L1)in short-term prognosis of patients with first acute ischemic stroke in non-atrial fibrillation.Methods According to the modified rankin scale(mRS)score,132 patients with first-episode AIS in non-atrial fibrillation population were divided into 93 patients with good prognosis(mRS ≤2 points)and 39 patients with poor prognosis(MRS＞2).Essen stroke risk score and serum OX-LDL and UCH-L1 were tested before the admission.Spearman correlation was used to analyze the differences between Essen stroke risk score and the levels of OX-LDL and UCH-L1,Logistic regression was used to analyze the risk factors of poor prognosis,and re-ceiver operating characteristic(ROC)curve was used to analyze the effects of Essen stroke risk score,OX-LDL and UCH-L1 levels and their combination on the prognosis evaluation of first-episode AIS in non-atri-al fibrillation population.Results The Essen stroke risk score in the poor prognosis group was higher than that in the good prognosis group(Z=-5.365,P＜0.001),and the concentrations of OX-LDL and UCH-L1 in serum were higher than those in the good prognosis group(Z=-6.152,P＜0.001;Z=-7.020,P＜0.001).Serum OX-LDL concentration and UCH-L1 concentration were positively correlated with Es-sen score(r=0.629,P＜0.001;r=0.598,P＜0.001).In multivariate Logistic regression analysis,Es-sen score,OX-LDL concentration and UCH-L1 concentration were independent factor affecting the prog-nosis of stroke.The ROC curve analysis showed that the Essen stroke risk score combined with OX-LDL and UCH-L1 had a curve area under the ROC curve of 0.896 for the prognosis of non-AF patients with first-episode acute ischemic stroke,with a sensitivity of 88.54％,and the specificity was 92.93％.Conclu-sion Essen stroke risk score combined with OX-LDL and UCH-L1 have a good predictive effect on the prognosis in patients of first acute ischemic stroke non-atrial fibrillation.The higher the Essen stroke risk score,OX-LDL and UCH-L1 levels,it shows the greater the risk of the poor prognosis.
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