Effects of sugammadex on neuromuscular blockade recovery and coagulation function in patients after thoracoscopic radical lung cancer surgery
Objective To investigate the effects of sugammadex on neuromuscular blockade recovery and coagulation function in patients with radical resection of lung cancer under thoracoscope.Methods 86 pa-tients with general anesthesia undergoing thoracoscopic radical esophagectomy were selected from February 2020 to January 2022 in the hospital,the patients were randomly divided into A group and B group.The 2 groups received the same anesthesia induction and intraoperative general anesthesia maintenance program,and neuromuscular blockade was assessed with a train-of-four(TOF)stimulus.When TOF count was≥2,group A received intravenous neostigmine(2 mg/kg)combined with atropine(0.5 mg/kg)and group B received intravenous sugammadex(2 mg/kg).The incidence of residual neuromuscular blockade was calculated 5,15 and 30 minutes after administration of neuromuscular blockade antagonists.The levels of plasma thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT)and fibrinogen(FIB)were observed at 5 minutes(T0)after injection of rocuronium,5 minutes(T1),15 mi-nutes(T2)and 30 minutes(T3)after administration of neuromuscular blockade antagonists.The time of tracheal catheter removal,nausea and vomiting of the patients were also recorded.Results The incidence of residual neuromuscular blockade in A group was significantly higher than that in B group in the calculat-ed 5 and 15 minutes after administration of neuromuscular blockade antagonists(100.00％vs 13.95％,65.12％vs 0.00％)(x2=64.939,41.517,P＜0.01).There was no significant difference in TT,APTT,PT and FIB between the 2 groups at the same time point(all P＞0.05).The extubation time of B group[(3.8±1.1)min]was shorter than that of A group[(13.9±4.3)min],the difference was statistically significant(t=14.922,P＜0.001).The incidence of respiratory depression was lower in the B group than that in A[0.00％vs 11.63％](x2=5.309,P=0.021).Conclusion Sugammadex can reverse the residual neuromuscular blockade induced by rocuronium within shorter time and decreased the incidence of residual muscular blockade in patients with radical resection of lung cancer under thoracoscope,and it can shorten the time of tracheal tube extubation after surgery and promote postoperative recovery.
radical resection of lung cancer under thoracoscopesugammadexresidual neuromuscular blockadecoagulation function
万方数据
维普
