Clinical effect of meglonella albus tablets combined with budesonide aerosol inhalation in treatment of acute pneumonia(AP)in children
Objective To explore the clinical effect of meglunella albus tablets combined with budesonide aerosol inhalation in the treatment of acute pneumonia(AP)in children.Methods A total of 92 children with AP admitted to the hospital from February 2021 to February 2023 were divided into observation group and control group by random number table method,with 46 cases in each group.The control group was given placebo treatment on the basis of conventional treatment,and the observation group was given oral glucomellae albus tablets on the basis of conventional treatment.The therapeutic effects of the 2 groups were evaluated after 5 days of the treatment,and the serum levels of inflammatory factors were detected by enzyme-linked immunoassay.Flow cytometry was used to detect the immune function,pulse shock pulmonary function apparatus was used to detect the respiratory mechanical index,and the safety of treat-ment was observed.Results Compared with control group(78.26%),the total effective rate of observa-tion group(95.65%)was increased(P<0.05).After the treatment,the levels of tumor necrosis factor-α[TNF-α(18.47±2.39),ng/L vs.(16.02±2.54)ng/L]and interleukin-10[IL-10,(105.68±12.59)ng/L vs.(146.92±17.33)ng/L]in observation group were lower than those in control group,and the levels of interferon-γ[IFN-γ,(161.40±20.76)ng/L vs.(189.76±24.59)ng/L]were higher than those in con-trol group(P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in both groups were increased after the treatment,and the immune indexes in the observation group were better than those in control group(P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in both groups were increased after the treat-ment,and the immune indexes in the observation group were better than those in control group(P<0.05).Airway resistance(R5)and resonance frequency(Fres)were decreased in both groups at 5 Hz after the treatment,and total compliance(Ct)was increased(P<0.05).All respiratory mechanical indexes in observation group were better than those in control group(P<0.05).The time of fever reduction,cough disappearance,lung rales disappearance and hospital stay in observation group were lower than those in control group(P<0.05).No obvious adverse reactions were observed in both groups during the treat-ment.Conclusion The combination of meglunella albus tablets and compound with budesonide aerosol in-halation can improve the therapeutic effect of AP children,improve body inflammatory response,improve respiratory function and immune function of the children,accelerate the improvement of clinical symp-toms,with high safety.
pediatric acute pneumonianefellaalbicans tabletsbudesonide for inhalationatomization ther-apycurative effect
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