Relationship and interaction between serum hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor A(VEGFA)and pain threshold in lumbar disc herniation with sciatica(LDHS)
Objective To investigate the relationship and interaction between the levels of hypoxia-inducible factor-1α(HIF-1α)and vascular endothelial growth factor A(VEGFA)in serum and pain threshold in pa-tients with lumbar disc herniation with sciatica(LDHS).Methods A total of 126 LDHS patients in the hospital from May 2020 to February 2023 were selected as case group,and 126 healthy subjects were se-lected as control group.Serum HIF-1α,VEGFA and pain threshold were compared between the 2 groups.Pearson correlation coefficient was used to analyze the relationship between serum HIF-1α and VEGFA levels and pain threshold.The relationship and interaction between serum HIF-1α and VEGFA level and pain threshold of LDHS patients were analyzed by multiple linear regression.Results The levels of serum HIF-1α and VEGFA in the case group were higher than those in the control group,and the pain threshold was lower than that in the control group(P＜0.05).The levels of serum HIF-1α(r=0.777,P＜0.001)and VEGFA(r=0.822,P＜0.001)in the case group were moderately positive correlated with pain threshold.The levels of serum HIF-1α(r=0.383,P＜0.001)and VEGFA(r=0.453,P＜0.001)in the control group were not significantly correlated with the pain threshold.Regardless of interaction,there was a linear correlation between serum HIF-1α and VEGFA levels and pain threshold(P＜0.05).The fit-ting equation was Y=-0.409+0.004 × HIF-1α+0.019 × VEGFA.All the predictors could explain 74.3％of the variance of dependent variable.Considering the interaction,the fitting equation for the pain threshold was Y=19.276+0.062 X HIF-1α+0.047 × Vegfa-0 × HIF-1α× VEGFA,and all the predictors could explain 74.7％of the variance of the dependent variable.When VEGFA expression was low,the re-lationship between serum HIF-1α expression and pain threshold was strong.When VEGFA expression was high,the relationship between serum HIF-1α expression and pain threshold was weak,and the straight line tends to be flat.Conclusion The levels of serum HIF-1α and VEGFA are closely related to the pain threshold of LDHS patients,and they have an interactive effect on the impact of pain threshold.
万方数据
维普
