Changes of serum β-endorphin(β-EP)and neurotensin(NT)levels in patients with postherpetic neuralgia(PHN)treated with spinal cord electrical stimulation and evaluation value of therapeutic responsiveness
Objective To investigate the changes of serum β-endorphin(β-EP)and neurotensin(NT)levels in patients with postherpetic neuralgia(PHN)and evaluate the therapeutic responsiveness.Methods A total of 108 PHN patients who received SCS treatment in thehospital from July 2021 to March 2023 were selected as the study group.The patients were further divided into well-responding patients and poorly-re-sponding patients based on their treatment outcomes after 6 months.Additionally,following the principle of 1∶1 random case-control study,108 PHN patients who underwent conventional drug treatment during the same period were selected as control group.The serum levels of β-EP and NT were measured and com-pared in each group.Results Before the treatment,the serum levels of β-EP and NT in the 2 groups were not significantly different(P＞0.05),but after the treatment,the serum levels of β-EP and NT in the study group were significantly higher than those in the control group(P＜0.05).Skin rash area ≥10 cm2 and initial treatment time＞3d were independent risk factors for poor PHN response of SCS,and itelevated serum levels of β-EP and NT were independent protective factors for poor PHN response of SCS(P＜0.05).ROC analysis showed that the AUC value of serum-βEP and NT levels alone in predicting the poor PHN response of SCS treatment was 0.776 and 0.793,respectively,and the AUC value was increased to 0.936 after the addition of multivariate Logistic regression model,which was higher than that of serum β-EP(Z=3.490,P=0.001)and NT(Z=3.430,P=0.001)levels predicted separately.Conclusion Serumβ-EP and NT levels in PHN patients are different before and after SCS treatment,and the serum β-EP and NT levels after the treatment are related to the long-term efficacy of SCS,and the combined detection can provide a reference for clinical evaluation of the long-term efficacy of SCS.
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维普
