Objective A meta-analysis was conducted to investigate the relationship between obstructive sleep apnea(OSA)and prostate cancer risk.Methods PubMed,EMBase,Web of Science,The Corchrane Library,China Knowledge Network(CNKI),China Biomedical Literature(CBM),and Wanfang databases were searched to collect all Chinese and English literatures that met the inclusion criteria,and then itman-ually searched according to the references retrospectively in published literature.The search was per-formed manually based on the reference tracing in published literature,and the year of search was from the establishment of the database to December 2023.2 evaluators independently screened the literature,ex-tracted the information,and evaluated the risk of bias of the included studies,and then performed meta-a-nalysis by using RevMan 5.4 software.To calculated Hazard Ratio(HR)for developing prostate cancer and obstructive sleep apnea,only multivariate cohort studies were included for analysis.Results The re-sults of the study,which included 7 cohort studies extracted from 2 164 articles,it showed that men with obstructive sleep apnea had a significantly higher risk of developing prostate cancer(HR:1.61,95％CI:1.02～2.53,P=0.04).Subgroup analysis showed that older men with obstructive sleep apnea had a sig-nificantly higher risk of prostate cancer and were more likely to develop cancer than non-older men(adjusted HR:2.57,95％CI:2.18～3.03,P＜0.01).There was no heterogeneity within subgroups(I2=0,P＞0.1),the difference between subgroups was statistically significant(I2=95.9％,P＜0.1),and the remaining subgroups analyzed were unable to differentiate between differences in this association.Conclusion The patients with OSA have a significantly increased and heterogeneous risk of prostate cancer,and the association is more pronounced in older men.
关键词
阻塞性睡眠呼吸暂停/前列腺癌/Meta分析/队列研究
Key words
obstructive sleep apnea(OSA)/prostate cancer/meta-analysis/cohort study
维普
万方数据