A study of correlation between weight-adj usted-waist index(WWI)and low eGFR in people aged 60 years and older
Objective To investigate the relationship between weight-adjusted-waist index(WWI)and esti-mated glomerular filtration rate(eGFR)in people aged 60 years and above,and to provide scientific refer-ence for the early prevention of renal impairment in the elderly.Methods Based on the baseline survey da-ta of the"Xinjiang multi-ethnic natural population cohort construction and health follow-up study",WWI was calculated by dividing waist circumference(cm)by the square root of body weight(kg),and Logistic regression model was used to explore the correlation between WWI and low eGFR,and restricted cubic spline(RCS)was used to explore the nonlinear dose-response relationship between WWI levels and low eGFR.Results A total of 10 987 study subjects were included,and the overall detection rate of low eGFR was 8.9％.After adjusting for relevant factors,Logistic regression showed that WWI was correlated with low eGFR(model 2:OR=1.085,95％CI:1.018～1.157,P=0.012;model 3:OR=1.098,95％CI:1.027～1.173,P=0.006).A nonlinear association between WWI and low eGFR was found using re-stricted cubic spline(P＜0.05).The reference value for the inflection point between WWI and the risk of developing low eGFR was 11.316.When WWI was＞11.316,the risk of developing low eGFR was in-creased by 0.281-fold for each unit increase in WWI(OR=1.281,95％CI:1.123～1.462).Conclusion There is a correlation between WWI and low eGFR in the population aged 60 years and above,and the risk of low eGFR is greater with the increasing of WWI when the population WWI＞11.316,this population should pay attention to the level of WWI,which will have a positive effect on the early detection and diagnosis of early treatment of their chronic renal impairment.
weight-adjusted-waist index(WWI)low eGFRelderly population
万方数据
维普
