Effect of abdominal obesity on acute exacerbation in patients with chronic obstructive pulmonary disease(COPD)
Objective To explore the impact of abdominal obesity on acute exacerbations of chronic obstruc-tive pulmonary disease(COPD).Methods Resident of Moyu County,Hotan,recruited on the basis of"Xinjiang multi-ethnic natural population cohort".Pulmonary function tests were performed to confirm COPD.All subjects were subjected to questionnaire survey and waist measurement,body composition tes-ting for visceral fat level,calculation of waist-to-height ratio,and weight-adjusted waist index(WWI).The patients were followed up for at least 1 year to assess the occurrence of acute exacerbations requiring hospitalization.The impact of abdominal obesity-related indicators on acute exacerbations was analyzed,and the predictive value of different abdominal obesity indicators on COPD acute exacerbations was com-pared.Results After follow-up of 631 patients with COPD,186 hospitalized cases of acute exacerbation of COPD were reported.Throughout the follow-up period,there were statistically significant differences in terms of age,history of pulmonary tuberculosis,smoking,secondhand smoke exposure,cooking and heating fuels and CAT scores between the patients with and without acute exacerbations of COPD(all P＜0.05).Single factor and models 1 and 2 demonstrated that waist circumference,waist-to-height ratio,WWI,and visceral fat had impacts on COPD acute exacerbations.An increase in the obesity index corre-sponded to an increase in the risk of COPD acute exacerbations.The waist-to-height ratio and visceral fat level's impact on COPD acute exacerbations were relatively stable.After multiple adjustments,the OR of waist-to-height ratio was 1.304(1.010～1.683),and the OR of visceral fat level was 1.912(1.122～3.257).Abdominal obesity-related indicators had predictive value for COPD acute exacerbations,with WWI having the largest area under the curve 0.614.Conclusion Abdominal obesity indicators such as waist-to-height ratio,WWI and visceral fat level are risk factors for COPD acute exacerbations,and inter-vention strategies to reduce abdominal obesity should be considered in the treatment of the COPD patients.
万方数据
维普
