目的 分析研究血清心血管调节肽(Salusin-β)、脂肪酸结合蛋白4(Fatty acid binding protein 4,FABP4)与子痫前期孕妇疾病严重程度和预后的关联.方法 以2021年3月-2022年3月武汉市汉阳医院妇产科收治的112例子痫前期孕妇为子痫前期组,根据患者疾病严重程度分为轻度子痫前期组和重度子痫前期组,选取同时期124例健康体检孕妇作正常血压组,测定各组孕妇的血清Salusin-β、FABP-4水平.记录各组孕妇分娩孕周、新生儿出生体重、血压恢复正常的时间.采用Pearson相关系数分析各组孕妇血清Salusin-β、FABP-4水平与预后指标的相关性.结果 子痫前期组和正常血压组孕妇平均年龄、平均孕次、平均产次、孕前平均体重指数、入院时平均孕周差异均无统计学意义(P＞0.05).与正常血压组相比,子痫前期组孕妇血清Salusin-β、FABP-4水平升高,差异均有统计学意义(P＜0.05).与轻度子痫组前期比较,重度子痫前期组血清Salusin-β、FABP-4水平均升高,孕妇分娩孕周缩短,新生儿体重降低,血压恢复正常的时间增长,差异均有统计学意义(P＜0.05).子痫前期组孕妇血清中Salusin-β、FABP-4水平与分娩孕周及新生儿出生体重均呈负相关,与血压恢复正常时间呈正相关(P＜0.05).正常血压组血清中Salusin-β、FABP4水平与分娩孕周、新生儿出生体重、血压恢复正常时间无相关性(P＞0.05).结论 子痫前期孕妇血清中Salusin-β、FABP-4水平与疾病严重程度及不良预后有相关性.
Correlation analysis of serum Salusin-β and fatty acid binding protein 4(FABP4)with disease severity and prognosis in pregnant women with preeclampsia
Objective To analyze and investigate the association between serum cardiovascular regulatory peptide(Salusin-β),fatty acid binding protein 4(FABP4)and the severity and prognosis of preeclampsia in pregnant women.Methods 112 pregnant women with preeclampsia admitted to the hospital in Wuhan from March 2021 to March 2022 were divided into mild preeclampsia group and severe preeclampsia group based on the severity of the disease.124 healthy pregnant women who underwent physical examination during the same period were selected as normal blood pressure group,and the serum salin levels of each group of pregnant women were measured-β and FABP-4 level.Recorded the gestational age,newborn birth weight and time for blood pressure to return to normal for each group of the pregnant women.Using Pearson correlation coefficient to analyzed serum salin levels of pregnant women in each group-β.There was correlation between FABP-4 levels and prognostic indicators.Results There was no statistically sig-nificant difference in average age,average number of pregnancies,average parity,average pre pregnancy body mass index and average gestational age at admission between preeclampsia group and normal blood pressure group(P＞0.05).Compared with normal blood pressure group,serum Salusin-β and FABP-4 levels in the preeclampsia group were increased,and the differences were statistically significant(P＜0.05).Compared with the mild preeclampsia group,the serum Salusin-β and FABP-4 levels in the severe preeclampsia group were increased,the gestational week of delivery was shortened,the newborns weight was decreased,and the time for blood pressure to return to normal was increased,with statistical signifi-cance(P＜0.05).Serum Salusin-β and FABP-4 levels in preeclampsia group were negatively correlated with gestational week and birth weight,and positively correlated with the time when blood pressure re-turned to normal(P＜0.05).There was no correlation between the levels of Salusin-β and FABP4 in the normal blood pressure group and gestational age week delivery,birth weight and the timeof recovery(P＞0.05).Conclusion Serum Salusin-β and FABP-4 levels in pregnant women with preeclampsia were corre-lated with disease severity and poor prognosis.
Salusin-βFatty acid binding protein 4(FABP4)preeclampsiapoor prognosis
万方数据
维普
