Study on value of modified CT severity index score(MCTSI)combined with serological indicators in evaluating prognosis of patients with acute pancreatitis(AP)
Study on value of modified CT severity index score(MCTSI)combined with serological indicators in evaluating prognosis of patients with acute pancreatitis(AP)
Objective To Explore the value of modified CT severity index score(MCTSI)combined with serological indicators in evaluating the prognosis of patients with acute pancreatitis(AP).Methods 248 patients with AP admitted to the hospital from January 2018 to January 2022 were selected as research subjects.According to their condition,the patients were divided into a mild group(n=152)and a moder-ate to severe group(n=96).All patients underwent pancreatic enhanced CT examination,blood routine,blood calcium and detection of the levels of procalcitonin(PCT),interleukin-6(IL-6),IL-17 and C-reac-tive protein(CRP).Mortality rates within 28 days were calculated,and differences in MCTSI scores and laboratory indicators were compared among AP patients with severity and prognosis.Results Multivariate Logistic analysis showed that MCTSI and the levels of blood amylase,lipase and PCT were independent risk factors affecting the severity of AP patients(P＜0.05).Within 28 days after onset,out of 248 pa-tients,196 survived and 52 died,with an overall survival rate of 79.03％.The survival rates of the mild and moderate severe groups were 91.4％(139/152)and 59.4％(57/96),respectively.The survival rates of the patients in the moderate severe group were significantly lower(X2=12.94,P＜0.001).ROC curve analysis showed that the AUC of MCTSI,PCT and blood calcium predicting patient mortality within 28 days were 0.870,0.785 and 0.679,respectively,with sensitivity of 72.6％,68.4％and 69.3％,and spe-cificity of 75.9％,69.7％and 64.4％,respectively.When the 3 are tested together,the AUC can be in-creased to 0.913.Multivariate Cox survival analysis showed that the levels of MCTSI,blood amylase,blood lipase and PCT were independent risk factors affecting the prognosis of AP patients.Conclusion The combination of MCTSI score and serological monitoring can improve the diagnostic efficacy of AP severity and prognosis assessment.
关键词
急性胰腺炎(AP)/改良CT严重指数评分(MCTSI)/血淀粉酶/血脂肪酶/降钙素原
Key words
acute pancreatitis(AP)/modified CT severity index score(MCTSI)/blood amylase/blood lipase/procalcitonin
维普
万方数据