首页|耳穴贴压联合新四联疗法治疗心衰加重的疗效观察

耳穴贴压联合新四联疗法治疗心衰加重的疗效观察

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目的 探讨耳穴贴压联合新四联疗法治疗心衰加重的疗效.方法 采用随机数字表法将心衰加重患者120例分成对照组和试验组,各60例.对照组实施新四联疗法,试验组在对照组治疗基础上加用耳穴贴压,均治疗2周.比较两组六分钟步行试验(6 minutes walk test,6MWT)结果、运动峰摄氧量(Peak oxygen uptake,PVO2)、每搏耗氧量(Oxygen consumption/heart rate,VO2/HR)、正常窦性心搏 RR 间期标准差(Standard deviation of NN intervals,SDNN)、全程相邻 窦 性心搏 RR 间期差值均方根(Root mean square successive differences be-tween successive R-R intervals,RMSSD)、低频功率(Low frequencies,LF)、高频功率(High fre-quencies,HF)、氨基末端脑钠肽前体(N-terminal pro-B-type natriuretic peptide,NT-proBNP)、肾素(Plasma renin activity,PRA)、血管紧张素 Ⅱ(Angiotensin Ⅱ,Ang Ⅱ)、醛 固酮(Aldosterone,ALD)水平.结果 试验组治疗总有效率为93.33%,高于对照组的80.00%(P<0.05).与治疗前比较,治疗后2周,两组PVO2、VO2/HR、6MWT、SDNN、RMSSD、LF及HF均升高,且试验组高于对照组(P<0.05).与治疗前比较,治疗后2周,两组NT-proBNP、PRA、Ang Ⅱ及ALD均下降,且试验组低于对照组(P<0.05).结论 耳穴贴压联合新四联疗法可有效改善心衰加重患者运动耐量、心率变异性,调节神经激素,降低NT-proBNP水平,临床疗效优于单一新四联疗法.
Observation on therapeutic effect of auricular acupoint therapy combined with new quadruple therapy on aggravated heart failure
Objective To explore the effect of auricular point therapy combined with new quadruple therapy in the treatment of aggravated heart failure.Methods Using a random number table,120 patients with worsening heart failure were divided into control group and experimental group,with 60 patients in each group.The control group was administered a new quadruple therapy,while the experimental group re-ceived additional auricular acupoint plaster therapy.Both groups underwent treatment for 2 weeks.To compare the results of the 6-minute walk test(6MWT),peak oxygen uptake(PVO2),oxygen consump-tion per heart rate(VO2/HR),standard deviation of normal sinus RR intervals(SDNN),root mean square of successive differences of normal sinus RR intervals(RMSSD),low frequencies(LF),high fre-quencies(HF),levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP),plasma renin activity(PRA),angiotensin Ⅱ(Ang Ⅱ)and aldosterone(ALD)between the 2 groups.Results The total effec-tive rate of treatment in the experimental group was 93.33%,which was higher than the 80.00%in the control group(P<0.05).Compared with before the treatment,after 2 weeks of the treatment,both groups showed an increase in PVO2,VO2/HR,6MWT,SDNN,RMSSD,LF and HF.Furthermore,the experimental group had higher values than control group(P<0.05).Compared with before the treat-ment,after 2 weeks of the treatment,both groups showed a decrease in NT-proBNP,PRA,Ang Ⅱ and ALD levels,and the experimental group had lower levels than the control group(P<0.05).Conclusion Auricular acupoint plaster therapy combined with the new quadruple therapy can effectively improve exercise toler-ance,heart rate variability,regulate neurohormones and lower NT-proBNP levels in patients with worse-ning heart failure.Its clinical efficacy is superior to that of the new quadruple therapy alone.

auricular point therapynew quadruple therapyaggravated heart failureheart rate variabilityexercise toleranceneurohormone

雷巧灵、李擎虎

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湖南中医药大学第二附属医院心血管内科,长沙 410000

湖南中医药大学第二附属医院消化内科,长沙 410000

耳穴贴压 新四联疗法 心衰加重 心率变异性 运动耐量 神经激素

2022年度湖南省中医药科研计划项目2022年度湖南省自然科学基金项目

C20220312022JJ30448

2024

新疆医科大学学报
新疆医科大学

新疆医科大学学报

CSTPCD
影响因子:0.76
ISSN:1009-5551
年,卷(期):2024.47(6)