Predictive value of nomogram model combined with short stature homeobox gene 2(SHOX2),RAS association domain family 1,isoform A(RASSF1A)and carcinoembryonic antigen(CEA)in occurrence of lung cancer
Objectives Short stature homeobox gene 2(SHOX2),RAS association domain family 1,iso-form A(RASSF1A)and carcinoembryonic antigen(CEA)wasused to construct a clinical model for pre-dicting the occurrence of lung cancer,and its predictive value was determined.Methods A total of 88 pa-tients with lung cancer and 219 patients with benign lung disease who were treated in the hospital from January 2020 to December 2022 were included.The demographics and clinical features of the 2 groups were compared,as well as the methylation levels of SHOX2 and RASSF1A genes in the bronchoalveolar lavage lavage fluid(Balf).Univariate analysis and multivariate Logistic regression analysis were used to screen out the variables affecting the occurrence of lung cancer and to construct nomogram.Results There were 36 patients(41.4%)positive for SHOX2 and 30 patients(34.5%)positive for RASSF1A in lung cancer group.CEA,cytokeratin 19 fragment(CYFRA21-1),squamous cell carcinoma antigen(SCCA)and pro-gastrin releasing peptide(Pro-GRP)were significantly different between the lung cancer group and control group(P<0.05).Logistic regression analysis showed that SHOX2,RASSF1A and CEA were independ-ent risk factors for pulmonary malignancy(P<0.05),and a nomogram model was constructed based on the above independent risk factors.The prediction model showed good differentiation ability(AUC=0.926,P=0.154),good consistency and benefit.Conclusion The nomogram model combined with SHOX2,RASSF1A and CEA has high predictive value and can provide basis for early diagnosis of lung cancer.
short stature homeobox gene two(SHOX2)RAS association domain family 1,isoform A(RASSF1A)carcinoembryonic antigen(CEA)lung cancernomogram