摘要
目的 探讨新疆居民体质指数(BMI)与骨质疏松症(OP)的关系,寻找降低骨质疏松症风险的BMI临界值,为骨质疏松症的预防提供科学依据.方法 基于"新疆多民族自然人群队列建设及健康随访研究"基线调查数据,骨密度(BMD)T分数作为评定骨质疏松症的标准.采用多因素Logistic回归模型分析BMI与OP的相关性,并使用限制性立方样条(RCS)探讨BMI与OP患病风险的关系,找出骨质疏松症风险的BMI临界值.结果 本研究共纳入13 804名具有完整数据的参与者,其中有812名(14.33％)男性骨质疏松症患者和1 386名(17.04％)女性骨质疏松症患者.单因素分析结果显示两组在年龄、社会经济地位、体力活动类型、是否患有高血压、骨折史方面具有统计学差异(P＜0.05);BMI与骨质疏松症患病相关,且与骨质疏松症的风险呈非线性关系(P＜0.01),男性、绝经前女性、绝经后女性RCS图中临界BMI值分别为24.47 kg/m2、24.79 kg/m2、27.37 kg/m2.结论 BMI与骨质疏松症的发病风险呈非线性关系,且不同性别和绝经状态下的个体在BMI值与骨质疏松症患病风险之间存在不同的临界点,这为不同人群利用BMI值预防骨质疏松症提供了一定的参考.
Abstract
Objective To explore the relationship between body mass index(BMI)and osteoporosis(OP)in Xinjiang residents,to find the critical value of BMI to reduce the risk of OP,and to provide a scientific basis for OP prevention.Methods Based on the baseline survey data of the Xinjiang Multi-ethnic Natural Population Cohort Construction and Health Follow-up Study,bone mineral density(BMD)T-score was used as criterion for assessing OP.A multifactorial Logistic regression model was used to analyze the cor-relation between BMI and OP,and restricted cubic spline(RCS)was used to explore the relationship be-tween BMI and the risk of developing OP,and to find out the critical value of BMI for OP.Results A to-tal of 13 804 participants with complete data were included in this study,including 812(14.33％)men with osteoporosis and 1 386(17.04％)women with OP.The results of univariate analysis showed statisti-cally significant differences between the 2 groups in terms of age,socioeconomic status,type of physical labor,having hypertension and history of fracture(P＜0.05);BMI was associated with the prevalence of OP and had a nonlinear relationship with the risk of OP(P＜0.01),and the critical BMI values in the RCS plots of males,pre-menopausal females and post-menopausal females were 24.47 kg/m2,24.79 kg/m2,and 27.37 kg/m,.Conclusion BMI has a nonlinear relationship with the risk of osteoporosis,and there are different critical points between BMI values and the risk of osteoporosis in individuals of different gen-ders and menopausal states,which provides a certain reference for the prevention of osteoporosis in differ-ent populations by utilizing BMI values.
基金项目
新疆维吾尔自治区自然科学基金项目(2022D01C437)
科技创新团队"天山创新团队"项目(2022TSYCTD0013)
NETL
NSTL
万方数据