Effects of sequential tirofiban on patients with acute ischemic stroke(AIS)after alteplase intravenous thrombolysis
Objective To observe the effects of sequential tirofiban treatment following alteplase intrave-nous thrombolysis in patients with acute ischemic stroke(AIS).Methods 60 patients with AIS admitted to Kunshan First People's Hospital from January 2021 to December 2023 were randomly divided into 2 groups of 30 cases each using the random number table method.The control group received standard alte-plase thrombolysis,while the study group received sequential tirofiban treatment after alteplase intrave-nous thrombolysis.The neurological deficit scores,doppler ultrasound cerebral blood flow,daily living a-bility,self-care ability,motor function and quality of life scores were compared before and after the treat-ment in both groups to evaluate the treatment effect.Results Before the treatment,compared with con-trol group,there were no significant differences in the scores of neurologic impairment,TCD pulsatility index,resistance index,maximum systolic velocity,end-diastolic velocity,average velocity,ability of dai-ly living,self-care,motor function and quality of life in study group(P＞0.05).After thetreatment,the neurological deficit scores,pulsatility index and resistance index in study group were significantly lower than those in control group,while the systolic peak flow velocity,end-diastolic flow velocity,mean flow velocity,daily living ability,self-care ability,motor function and quality of life scores were significantly higher(P＜0.05).The study group also had a higher overall effective rate compared to the control group,with a statistically significant difference(P＜0.05).Conclusion Sequential tirofiban treatment after alte-plase intravenous thrombolysis in AIS patients can significantly reduce the severity of neurological deficits,improve hemodynamic indicators,enhance daily living abilities,self-care abilities,and motor functions,and improve the quality of life,making it worthy of clinical promotion.
万方数据
维普
