Prognostic correlation of serum C-reactive protein to albumin ratio(CAR),eosinophil to lymphocyte ratio(ELR)and acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in patients with pulmonary infection
Prognostic correlation of serum C-reactive protein to albumin ratio(CAR),eosinophil to lymphocyte ratio(ELR)and acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in patients with pulmonary infection
Objective To explore the predictive value of C-reactive protein to albumin ratio(CAR)and eo-sinophil to lymphocyte ratio(ELR)for the prognosis of the patients with acute exacerbation of chronic ob-structive pulmonary disease(AECOPD)complicated with pulmonary infection.Methods From January 2019 to June 2022,180 AECOPD patients were recruited.Based on the presence of pulmonary infection,the 180 AECOPD patients were divided into infection group(105 cases)and non-infection group(75 ca-ses).Among the infection group,105 patients were further categorized into good prognosis group(62 ca-ses)and poor prognosis group(43 cases)based on their prognosis after hospitalization.The serum CAR and ELR levels of all subjects were measured,and Logistic regression analysis was conducted to identify the risk factors influencing the prognosis of AECOPD patients with pulmonary infection.ROC curve anal-ysis was performed to assess the predictive value of CAR and ELR,both individually and in combination,for the prognosis of AECOPD patients with pulmonary infection.Results Compared with non-infected group,the serum levels of CAR(t=45.25,P＜0.001)and ELR(t=20.11,P＜0.001)in infected group patients were increased.Compared with good prognosis group,the serum levels of CAR and ELR in the poor prognosis group patients were increased(all P＜0.05),and the patients had higher age,longer course,higher proportion of combined pulmonary heart disease and non-invasive ventilator treatment,as well as lower levels of FEV1,FEV1/FVC and FVC(P＜0.05).The Logistic results showed that the course,non-invasive ventilator treatment,CAR and ELR were independent risk factors affecting the poor prognosis of AECOPD patients with pulmonary infection.The ROC results showed that the AUC for ser-um CAR and ELR separately predicting the prognosis of AECOPD patients with pulmonary infection was 0.778 and 0.787,respectively,and the AUC for their combined prediction was 0.875,significantly greater than the AUC for CAR and ELR separately(Z=2.128,3.236,P＜0.05).Conclusion The serum levels of CAR and ELR in AECOPD patients with pulmonary infection were increased,and their combined detec-tion can improve the level of prognosis evaluation for AECOPD patients with pulmonary infection.
关键词
C反应蛋白/白蛋白比值/嗜酸性粒细胞/淋巴细胞比值/慢性阻塞性肺疾病/肺部感染
Key words
C-reactive protein to albumin ratio(CAR)/eosinophil to lymphocyte ratio(ELR)/chronic ob-structive pulmonary disease(COPD)/pulmonary infection
维普
万方数据