TNF-α、IL-17与PCOS不孕患者IVF-ET助孕结局的关系及交互作用分析

Analysis of relationship and interaction between tumor necrosis factor-α(TNF-α),interleukin-17(IL-17)and in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy outcome in infertility patients with polycystic ovary syndrome(PCOS)

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维普
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中文摘要：目的探讨肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)与多囊卵巢综合征(P-COS)不孕患者体外受精-胚胎移植(IVF-ET)助孕结局的关系及其交互作用.方法回顾性分析2022年1月至2023年12月北京市大兴区人民医院收治的126例PCOS不孕患者的临床资料,患者均给予IVF-ET治疗,将IVF-ET 35 d后患者宫内妊娠且有胎心搏动者纳入临床妊娠组,否则纳入未妊娠组.分析影响PCOS不孕患者IVF-ET助孕结局的因素,分析TNF-α与IL-17的交互作用对PCOS不孕患者IVF-ET助孕结局的影响,分析TNF-α、IL-17对PCOS不孕患者IVF-ET助孕结局的预测价值.结果临床妊娠患者62例,未妊娠患者64例.Logistic回归分析显示优质胚胎率(OR=0.331,95％CI:0.148～0.738)、TNF-α 水平(OR=3.494,95％CI:1.438～8.491)、IL-17 水平(OR=3.144,95％CI:1.281～7.569)是影响 PCOS 不孕患者 IVF-ET 助孕结局的因素(P＜0.05).TNF-α与IL-17对PCOS不孕患者IVF-ET助孕结局存在正向交互作用,两者交互助孕结局效应为两者单独作用之和的1.384倍(95％CI:1.012～1.894).ROC曲线分析显示,TNF-α、IL-17及两者联合预测PCOS不孕患者IVF-ET助孕结局的AUC分别为0.713(95％CI:0.610～0.816)、0.707(95％CI:0.594～0.821)、0.883(95％CI:0.815～0.952).结论 TNF-α、IL-17与PCOS不孕患者IVF-ET助孕结局有关,二者在不良助孕结局中具有正向交互作用,其联合预测助孕结局效能良好.

外文摘要：Objective To investigate the relationship and interaction between tumor necrosis factor-α(TNF-α),interleukin-17(IL-17)and in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy outcomes in infertility patients with polycystic ovary syndrome(PCOS).Methods The clinical data of 126 patients with PCOS infertility admitted to thehospital from January 2022 to December 2023 were retrospectively an-alyzed.The factors influencing the outcome of IVF-ET fertility in patients with PCOS infertility were ana-lyzed,the interaction between TNF-α and IL-17 was analyzed on the outcome of IVF-ET fertility in pa-tients with PCOS infertility,and the predictive value of TNF-α and IL-17 on IVF-ET fertility outcomes in patients with PCOS infertility was analyzed.Results There were 62 clinical pregnant patients and 64 non-pregnant patients.Logistic regression analysis showed high quality embryo rate(OR=0.331,95％CI:0.148～0.738),TNF-α level(OR=3.494,95％CI:1.438～8.491),IL-17 level(OR=3.144,95％CI:1.281～7.569)were the factors affecting the outcome of IVF-ET assisted pregnancy in PCOS infertile pa-tients(P＜0.05).There was a positive interaction between TNF-α and IL-17 on the assisted pregnancy outcome of IVF-ET in PCOS infertility patients,and the effect of TNF-α and IL-17 on the assisted preg-nancy outcome was 1.384 times that of the sum of the 2 independent effects(95％CI:1.012～1.894).ROC curve analysis showed that theAUC of TNF-α,IL-17 and their combination in predicting the outcome of IVF-ET assisted pregnancy in PCOS infertility patients were 0.713(95％CI:0.610～0.816),0.707(95％CI:0.594～0.821)and 0.883(95％CI:0.815～0.952),respectively.Conclusion TNF-α and IL-17 are related to IVF-ET assisted pregnancy outcomes in PCOS infertility patients,and the two have a posi-tive interaction in adverse assisted pregnancy outcomes,and their combined predictive efficacy is good.

外文关键词：

polycystic ovary syndrometumor necrosis factor-α(TNF-α)interleukin-17(IL-17)in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy outcome

作者：

陈晨

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作者单位：

北京市大兴区人民医院产科,北京 102600

关键词：

多囊卵巢综合征(PCOS) 肿瘤坏死因子-α(TNF-α) 白细胞介素-17(IL-17) 体外受精-胚胎移植(IVF-ET) 助孕结局

基金：

北京市科技计划项目

项目编号：

Z211200004010169

出版年：

2024

DOI：

10.3969/j.issn.1009-5551.2024.09.008

新疆医科大学学报

新疆医科大学

新疆医科大学学报

CSTPCD

影响因子：0.76

ISSN：1009-5551

年,卷(期)：2024.47(9)