Epidemiological characteristics of patients with different types of gallstones and correlation analysis of stone components with lipid metabolism and liver function indexes
Objective To study the epidemiological characteristics of thepatients with different types of gall-stones and the correlation between stone components and lipid metabolism and liver function.Methods 308 patients with simple gallstones admitted to the hospitalfrom January 2021 to December 2023 were selected as study objects.The second generation of intelligent infrared spectroscopic calculi analyzer was used to analyze the composition of the calculi specimens,and the patients were divided into cholesterol calculi group,bile pigment calculi group,cholesterol-bile pigment mixed calculi group and other calculi group ac-cording to the types of gallstones.Epidemiological characteristics of all patients were collected,and lipid metabolism and liver function indicators were recorded.Spearman correlation analysis was used to evalu-ate the relationship between the contents of cholesterol,bilirubin,cholic acid and lipid metabolism and liv-er function in different types of gallstone groups.Results Among 308 specimens of gallstones,145 were cholesterol-type stones,91 were cholecithal stones,52 were cholesterol-cholecithal stones and 20 were other types of stones.There were significant differences in gender,BMI and liver disease occurrence a-mong the 4 groups(P＜0.05).2 comparative analysis,according to the results of comparing with the type of cholesterol stone group,bile pigment type group,the cholesterol to bile pigment mixed stones and other types of stones in groups of women,the proportion of BMI,24 kg/m2 or high cholesterol,serum cholesterol(CHOL),3 acyl glycerin(TG)were significantly reduced,the difference were statistically sig-nificant(P＜0.05).The serum alkaline phosphatase(ALP)level in bile pigment type stone group and cholesterol-bile pigment mixed stone group was significantly higher than that in cholesterol type and other types of the patients,and the total bilirubin(TBIL)level in bile pigment type stone group was significant-ly higher than that in the other 3 groups,with statistical significance(P＜0.05).The content of choles-terol in cholesterol type stones was significantly higher than that in the other 3 groups,the content of bili-rubin in bile pigment stones was significantly higher than that in the other 3 groups,and the content of cholic acid in other types of stones was significantly higher than that in the other 3 groups,with statistical significance(P＜0.05).There was a significant positive correlation between cholesterol content and CHOL level in cholesterol type calculus group(P＜0.05).There was a significant positive correlation be-tween the content of bile pigment and the ALP level in patients with bile pigment type stones(P＜0.05).Conclusion There are differences in gender,BMI,hyperlipidemia,serum CHOL,TG,ALP and TBIL in patients with different types of gallstones.
gallstoneepidemiologylipid metabolismliver function
维普
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