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产前超声诊断胎儿肾盂增宽与染色体异常及不良妊娠结局的相关性

Correlation between prenatal ultrasound diagnosis of fetal renal pelvis widening,chromosomal abnormalities and adverse pregnancy outcomes

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目的 探讨产前超声诊断胎儿肾盂增宽与染色体异常及不良妊娠结局的相关性.方法 回顾性分析南方医科大学第十附属医院/东莞市人民医院2021年6月至2023年6月产前二维超声诊断为胎儿肾盂增宽的临床资料,根据是否合并有其它超声异常分为孤立性肾盂增宽组(n=84)和非孤立性肾盂增宽组(n=27),孤立性肾盂增宽组中再依据肾盂增宽程度分为轻、中、重度3组,比较不同分组间胎儿染色体异常及不良妊娠结局的差异.结果 111例胎儿中,孤立性增宽组(84例)和非孤立性肾盂增宽组(27例)中染色体异常分别为4例(4.76%)和5例(18.51%),不良妊娠分别为8例(9.52%)和12例(44.44%),差异均具有统计学意义(P<0.05);其中孤立性肾盂增宽组中轻、中、重度组胎儿染色体异常率分别为0%、11.11%、3.22%,不良妊娠率分别为0%、11.11%、16.12%,差异均具有统计学意义(P<0.05).结论 当肾盂增宽合并其它超声异常时,胎儿染色体异常率和不良妊娠率随之增加.孤立性肾盂增宽程度与染色体异常率及不良妊娠率无明显相关性.
Objective To explore the correlation between prenatal ultrasound diagnosis of fetal renal pelvis widening,chromosomal abnormalities and adverse pregnancy outcomes.Methods Retrospective analysis of clinical data of fetuses diagnosed with widened renal pelvis by prenatal 2-dimensional ultrasound at the hospital from June 2021 to June 2023.According to the presence of other ultrasound abnormalities,the group was divided into isolated renal pelvis widening group(n=84)and non isolated renal pelvis widening group(n=27).The isolated renal pelvis widening group was further divided into mild,moderate,and se-vere groups based on the degree of renal pelvis widening.The differences in fetal chromosomal abnormali-ties and adverse pregnancy outcomes between different groups were compared.Results Among 111 fetu-ses,there were 4 cases(4.76%)and 5 cases(18.51%)of chromosomal abnormalities in isolated widening group(84 cases)and non isolated widening group(27 cases),respectively.The adverse pregnancy rates were 8 cases(9.52%)and 12 cases(44.44%),respectively,and the differences were statistically signifi-cant(P<0.05).The rates of fetal chromosomal abnormalities in the solatedrenal pelvis widening group were 0%,11.11%and 3.22%,respectively,and the rates of adverse pregnancy were 0%,11.11%and 16.12%,respectively.The differences were statistically significant(P<0.05).Conclusion When the re-nal pelvis widens and other ultrasound abnormalities are present,the rate of fetal chromosomal abnormali-ties and adverse pregnancy increases accordingly.There is no significant correlation between the degree of isolated renal pelvis widening and the rates of chromosomal abnormalities and adverse pregnancy.

prenatal ultrasoundrenal pelvis wideningchromosome abnormalityadverse pregnancy outcomes

梁佳乐、陈静、刘芳、罗海波

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南方医科大学第十附属医院/东莞市人民医院超声科,广东 东莞 523000

产前超声 肾盂增宽 染色体异常 不良妊娠结局

广东省医学科研基金指令性课题项目

C2022125

2024

新疆医科大学学报
新疆医科大学

新疆医科大学学报

CSTPCD
影响因子:0.76
ISSN:1009-5551
年,卷(期):2024.47(9)