Influence factors and construction of nomogram model of swallowing dysfunction after early laryngeal cancer surgery
Objective To explore the factors influencing swallowing dysfunction after early laryngeal cancer surgery and to develop a nomogram model.Methods Data of 183 patients with early laryngeal cancer treatedin the hospital from January 2020 to December 2023 were retrospectively analyzed.According to whether the patients had swallowing dysfunction after the the surgery,the patient were divided into case group(those with swallowing dysfunction)and the control group(those without swallowing dysfunction).Univariate and multivariate Logistic regression analyses were conducted to screen out the factors of swallo-wing dysfunction after early laryngeal cancer surgery.A nomogram model was developed and its predictive performance was evaluated.Results Among the 18 patients with early laryngeal cancer,59(32.24％)de-veloped swallowing dysfunction after the surgery,while the remaining 124(67.76％)did not.The univari-ate analysis showed that the age of the patients,history of laryngopharyngeal reflux,surgical,degree of trismus and the highest pain score within 1 week after the surgery were significantly different between the patients who developed swallowing dysfunction and those who did not(P＜0.05).The multivariate analy-sis showed that all these factors were independent influencing factors for swallowing dysfunction after early laryngeal cancer surgery(P＜0.05).A nomogram model was constructed based on the above 6 factors,with a concordance index(CI)of 0.814 and an average error of the standard calibration curve of 0.014.Age,history of laryngopharyngeal reflux,surgical approach,degree of trismus,highest pain score within 1 week surgery,and the area under the receiver operating characteristic(ROC)curve for predicting dys-phagia after early laryngeal cancer surgery using the nomogram were 0.736,0.748,0.630,0.848,0.06 and 0.957,respectively,indicating that the model has high predictive accuracy.Conclusion The nomo-gram model constructed in this study can effectively predict the risk of postoperative swallowing dysfunc-tion in patients with early laryngeal cancer,which is helpful to help patients with early laryngeal cancer carry out risk management and develop personalized treatment plans in advance,and improve the postoper-ative quality of life of patients with laryngeal cancer.
laryngeal cancerswallowing dysfunctionnomogram model
万方数据
维普
