Relationship between expression of triggering receptors expressed on myeloid cells-2(TREM2)and prognosis of advanced esophageal squamous cell carcinoma(ESCC)with neoadjuvant chemoradiotherapy
Objective To investigate the relationship between the expression of triggering receptors ex-pressed on myeloid cells-2(TREM2)gene and the prognosis of neoadjuvant chemoradiotherapy in ad-vanced esophageal squamous cell carcinoma(ESCC).Methods The data of 175 patients with locally ad-vanced ESCC admitted to the hospital from March 2022 to June 2023 were retrospectively analyzed.All pa-tients received neoadjuvant chemoradiation plus radical resection.According to the prognosis of advanced ESCC patients,the patients were divided into pathological complete response(pCR)group and non-PCR group.The expression level of TREM2 in cancer tissue was compared with the clinical data of the 2 groups.The non-PCR influencing factors of advanced ESCC neoadjuvant chemoradiotherapy were ana-lyzed.The non-PCR predictive value of TREM2 expression in cancer tissues in patients with advanced ES-CC neoadjuvant chemoradiotherapy was analyzed using receiver operating characteristic curve(ROC).Re-sults The ESCC cancer tissues with TREM2 expression level was higher than adjacent tissues(P＜0.05).In 175 ESCC patients,the pCR rate was 34.86％(61/175).The proportion of N1 stages in pCR group was lower than that in non-PCR group(P＜0.05).The pCR group with TREM2 expression level in cancer tissuewas lower than non-PCR group(P＜0.05).Age ≥60 years(OR=3.184,95％CI:1.670～6.070),N1 stage(OR=3.442,95％CI:1.805～6.563),TREM2 expression level in cancer tissues(OR=3.943,95％CI:2.068～7.519)were non-PCR independent risk factors in patients with advanced ESCC neoadjuvant chemoradiotherapy(P＜0.05).The expression level of TREM2 in cancer tissue predicted the ROC area under the curve of non-pCR in patients with advanced ESCC neoadjuvant chemoradiotherapy was 0.844(P＜0.05).Conclusion The expression of TREM2 gene is up-regulated in cancer tissues of ad-vanced ESCC patients,and the level of TREM2 expression in cancer tissue is important for predicting the prognosis of advanced ESCC patients with neoadjuvant chemoradiotherapy.
triggering receptors expressed on myeloid cells-2(TREM2)advanced esophageal squamous cell carcinoma(ESCC)prognosisNeoadjuvant chemoradiotherapyinfluencing factorspredictive value
万方数据
维普
