摘要
目的 探究外周血中淋巴细胞/单核细胞比值对乳腺癌患者中预后评估作用.方法 收集2013年-2018年军区总医院接受手术切除的乳腺癌患者82例,分析淋巴细胞单核细胞比值与患者临床资料、预后评估的价值.结果 (1)根据无疾病生存期,建立ROC曲线,根据约登指数取最佳敏感度及特异度,得出淋巴细胞单核细胞比值临界值为5.78.(2)按照LMR5.78分组,通过单因素方差分析得出术前高值LMR组与低值LMR组的临床资料中,年龄、绝经状态、TNM分期、雌激素受体、孕激素受体等均与LMR分组无统计学意义,DFS与LMR分组有统计学意义(P＜0.05).(3)生存函数分析,高LMR组乳腺癌患者的DFS明显延长,差异有统计学意义(P＜0.05).结论 术前LMR≥5.78是乳腺癌预后有力的因素,术前LMR检测方便、低廉、结果稳定可作为乳腺癌患者预后的生物学标志物之一.
Abstract
Objective To explore the role of lymphocyte/mononucleosis ratio in peripheral blood on prognosis evaluation in breast cancer patients.Methods Collected 82 cases of breast cancer patients who underwent surgical removal at military general hospital from 2013 to 2018,analyzed the value of lymphocyte mononucleosis ratio and patient clinical data and prognostic evaluation.Results(1)According to disease-free survival,the ROC curve was established,and the critical value of lymphocyte monocyte ratio was 5.78 based on the optimal sensitivity and specificity of the Joden index.(2)According to the lymphocyte mononucleosis ratio threshold of 5.78,through single-factor variance analysis,the preoperative high-value LMR group and low-value LMR group clinical data,age,menopause,TNM staging,estrogen receptors,progesterone receptors and LBR grouping were not statistically significant,DFS and LMR grouping was statistically significant(P＜0.05).(3)Through the analysis of survival function,the DFS of breast cancer patients in the high LMR group was significantly prolonged,and the difference was statistically significant(P＜0.05).Conclusion Preoperative LMR ≥5.78 is a powerful factor in the prognosis of breast cancer,and preoperative LMR detection is convenient,inexpensive and stable,which can be used as one of the biomarkers for the prognosis of breast cancer patients.
基金项目
昌吉州人民医院科研项目(zyy2021qn-03)
NETL
NSTL
万方数据