Risk factors of liver injury in 259 children with acute lymphoblastic leukemia after chemotherapy
Objective To summarize the occurrence of liver injury in the course of chemotherapy in children with acute lymphoblastic leukemia(ALL)and to investigate the risk factors for liver function injury resulting from chemotherapy.Methods A retrospective analysis was performed on the clinical data of 259 ALL patients who were treated with chemotherapy in the Department of Pediatrics of the Affiliated Hospital of Xinjiang Medical University from January 2019 to April 2022.The data of age,gender,body mass index(BMI),chemotherapy stage,hemoglobin level,albumin level,infection and extramedullary prophylaxis were collected.Univariate analysis was performed first to screen out the factors with significant influence,and then logistic regression was used for multivariate analysis.Results Univariate analysis showed that gender,age,BMI,chemotherapy stage and whether to use high-dose methotrexate had no statistical significance on the occurrence of liver injury after chemotherapy(P＞0.05).Intrathecal injection,anemia,hypoproteinemia and infection were more likely to cause liver injury after chemotherapy,and the differences were statistically significant(P＜0.05).Logistic regression showed that hypoproteinemia was an independent risk factor for liver injury after chemotherapy.Conclusion The incidence of liver injury in children with ALL is associated with anemia,hypoproteinemia,infection and extramedullary prophylaxis.Hypoproteinemia is an independent influencing factors of liver injury after chemotherapy.Proper treatment is required to reduce the incidence of liver injury after chemotherapy.
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