Clinical application of immunoglobulin determination and immunoelectrophoresis in the diagnosis of multiple myeloma
Objective To explore the application and value of immunoglobulin quantitative detection,immunoprotein elec-trophoresis and immunofixation electrophoresis in the diagnosis of multiple myeloma(MM).Methods Serum of 58 patients who were diagnosed with MM in our hospital from June 2020 to June 2021 were collected,and the quantification of serum immunoglobulins(IgG,IgA,IgM,kappa light chain)and λ light Chain(lambda light chain)were detected.Serum protein electrophoresis and immunofixation electrophoresis were also performed to evaluate the clinical application value of the above detection indicators in the diagnosis of MM.Results 41 cases of all 58 MM patients were detected to have M protein by protein electrophoresis,and the positive rate was 70.7％.54 cases were positive and the positive rate was 93.1％by immunofixation electrophoresis detection,and the difference was statistically sig-nificant.In addition,there were 32 cases of IgG type(55.2％),8 cases of IgA type(13.8％),3 cases of IgM type(5.1％),and 8 cases of light chain type(13.8％).At the same time,the corresponding type of immunoglobulin and light chain were increased and other compo-nents of immunoglobulin and light chain are reduced.Conclusion Immunoglobulin and light chain detection,as well as immunoprotein electrophoresis,are important methods for clinical screening of multiple myeloma.Immunofixation electrophoresis can quickly and accu-rately diagnose and classify MM,and can be used as one of the routine detection methods for MM.
Multiple myelomaImmunoprotein electrophoresisFixed electrophoresisClinical value
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