目的 探讨舒芬太尼复合帕瑞昔布对胸外科手术患者术后镇痛的效果.方法 从本院胸外科收治的开展手术治疗的患者中择50例作为研究对象,研究时段2021年4月-2022年5月,将所选患者应用随机数表法分为两组各25例.对照组采用舒芬太尼术后镇痛,观察组采用舒芬太尼复合帕瑞昔布进行术后镇痛管理,观察两组患者术后镇痛、镇静效果及安全性.结果 术后镇痛与镇静效果评估,术后即刻组间VAS评分、Ramsay评分差异较小,P＞0.05;术后观察组VAS评分更低,Ramsay评分更高,P＜0.05.血流动力学评估,术后即刻组间平均动脉压参数、心率参数均无较大差异性,P＞0.05;术后观察组平均动脉压、心率指标更高,临床体征指标参数更为稳定,P＜0.05,且观察组舒芬太尼用量更低,24 h PCA次数更少,P＜0.05.炎性因子水平,观察组各时间段IL-6指标、C反应蛋白指标、TNF-ɑ指标均低于对照组,P＜0.05.术后不良反应发生率观察组对照组差异较小,组间术后安全性相当,P＜0.05.结论 胸外科术后镇痛采用舒芬太尼复合帕瑞昔布,不仅可以提高镇痛效果、减以对生命体征的影响,而且安全性高,值得推广.
Application of sufentanil combined with parecoxib in postoperative analgesia after thoracic surgery
Objective To investigate the effect of Sufentanil combined with parecoxib on postoperative analgesia in patients un-dergoing thoracic surgery.Methods 50 patients undergoing surgical treatment in the thoracic surgery department of our hospital from April 2021 to May 2022 were selected as the study objects.The selected patients were divided into two groups with 25 cases in each group by random number table method.The control group was treated with sufentanil for postoperative analgesia,and the observation group was treated with sufentanil combined with parexib for postoperative analgesia management.The postoperative analgesia,sedation effects and safety of the two groups were observed.Results Considering of postoperative analgesia and sedation,VAS score and Ram-say score had little difference between two groups immediately after surgery(P＞0.05).VAS score was lower and Ramsay score was higher in the observation group(P＜0.05).Hemodynamic evaluation showed that there were no significant differences in mean arterial pressure and heart rate between two groups immediately after operation(P＞0.05).After operation,the mean arterial pressure and heart rate indexes in the observation group were higher,and the clinical signs index parameters were more stable(P＜0.05),and the sufentanil dosage in the observation group was lower,and the number of 24 h PCA times was less(P＜0.05).The levels of inflammato-ry factors,IL-6 index,C-reactive protein index and TNF-alpha index in the observation group were lower than those in the control group at all time periods,(P＜0.05).There was little difference in the incidence of postoperative adverse reactions between the obser-vation group and the control group,and the postoperative safety was also similar between the two groups(P＜0.05).Conclusion The use of sufentanil combined with parecoxib for postoperative analgesia after thoracic surgery can not only improve the analgesic effect and reduce the impact on vital signs,but also have high safety,which is worth popularizing.
Thoracic SurgeryPostoperative analgesiaSufentanilParecxibHemodynamic indexesIncidence rate of adverse re-actions
NETL
NSTL
万方数据
