Application value of BNP,CK-MB combined with heart rate variability in evaluating short-term occurrence of MACE after acute myocardial infarction
Objective To explore the predictive value of heart rate variability(HRV)combined with BNP and CK-MB for short-term MACE caused by acute myocardial infarction(AMI).Methods 76 patients with AMI treated with percutaneous coronary inter-vention(PCI)were selected,and 28 cases in the observation group developed MACE within 3 months.48 cases in the control group did not develop MACE within 3 months.MACE of patients in the observation group was recorded,serum BNP and CK-MB levels of both groups at 24 h after PCI were monitored,and HRV was monitored for Logistic analysis.Results After PCI,the levels of BNP and CK-MB in the observation group were higher than those in the control group(P<0.05).During the perioperative period of PCI,the time domain parameter indicators SDNN,SDANN,rMSSD levels,and frequency domain indicator LF in the observation group were sig-nificantly lower than those in the control group at different time periods(P<0.05),while the frequency domain indicator HF was sig-nificantly higher than that in the control group(P<0.05).ROC curve analysis showed that effectiveness of combined evaluation of AUC and protective factors for the incidence of MACE was significantly higher than that of the single indicators BNP,CK-MB,SDANN,and SDNN(P<0.05).The sensitivity(92.75%)and specificity(90.64%)of the combined protective factors were higher than those of a single indicator(P<0.05).Conclusion BNP and CK-MB levels were higher in AMI patients with short-term MACE after PCI,while SDNN,SDANN,rMSSD and LF levels were lower in HRV and HF levels were higher.Multivariate regression analysis showed that BNP,CK-MB,SDANN and SDNN were protective factors for MACE occurrence,which have high sensitivity and specificity.
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