Application value of TCT combined with HR-HPV detection in early screening of cervical cancer and precancerous lesions
Objective To explore the practical value and effectiveness of liquid-based thin-layer cell test(TCT)combined with high-risk human papillomavirus(HR-HPV)detection in the early screening of cervical cancer and precancerous lesions.Meth-ods 2000 patients with cervical cancer and precancerous lesions were selected for early screening from January 2020 to January 2023.TCT and HR-HPV were performed.The diagnostic gold standard was based on the pathological results,and the consistency be-tween the single and combined detection of TCT and HR-HPV and the pathological results was compared.Results Pathological ex-amination showed among 2000 patients,396 cases were positive and 1604 cases were negative.For TCT+HR-HPV combined detec-tion method,its sensitivity was 94.41％,its specificity was 98.50％and its accuracy was 98.80％.All data were significantly higher than those of TCT single detection which was 80.00％,87.83％and 86.95％respectively,and those of HR-HPV single detection which was 82.10％,94.81％and 92.40％respectively,and the difference was statistically significant(P＜0.05).The positive and negative predic-tive values of TCT+HR-HPV were 93.93％and 98.62％,which were significantly higher than those of TCT single detection which was 45.45％,97.19％and those of HR-HPV single detection which was 78.78％and 95.76％.The misdiagnosis rate and missed diagnosis rate were 5.58％and 1.51％which were significantly lower than those of TCT single detection being 20.00％and 12.17％,and those of HR-HPV single detection which was 17.89％and 5.18％,and the difference was statistically significant(P＜0.05).Conclu-sion Early screening of cervical cancer and precancerous lesions by TCT+HR-HPV detection can significantly improve the accu-racy of diagnosis,contribute to early clinical diagnosis and treatment,improve the quality of diagnosis and treatment,and prolong the survival period of patients.
NETL
NSTL
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