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临床药师在肿瘤科从不同角度参与用药方案优化分析

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目的 总结临床药师在肿瘤科开展药物治疗方案优化的工作经验,促进临床合理用药.方法 临床药师从不同角度参与患者用药方案优化,分别参与1例食管癌伴带状疱疹患者使用利巴韦林症状无缓解;1例肺癌伴肺部和尿路感染,使用头孢哌酮舒巴坦尿路症状无改善;1例乳腺癌患者,化疗后骨髓抑制伴血流感染,给予头孢哌酮舒巴坦2g ivgtt q12h 3d仍高热;1例胃癌伴心脏瓣膜病,长期服用华法林抗凝,服用卡培他滨后出现牙龈出血等4个案例.结果 4个案例中,临床药师提出的优化方案全部被医生采纳,案例1将利巴韦林调为阿昔洛韦后疱疹消失;案例2将头孢哌酮舒巴坦调为哌拉西林他唑巴坦后,肺部和尿路症状均明显好转;案例3将头孢哌酮舒巴坦用法由q12h改为q8h,体温恢复正常;案例4将华法林每天由3.75 mg降为3.125 mg,牙龈未再出血.结论 临床药师可从药物适应症、药动学、相互作用及感染部位等方面参与用药方案优化,为药师参与药物治疗方案优化提供参考,更好保障患者用药安全.
Clinical pharmacists participate in optimizing medication plans from different perspectives in the oncology department
Objective To summarize the work experience of clinical pharmacists in optimizing drug treatment plans in the oncol-ogy department,and promote rational drug use in clinical practice.Method Clinical pharmacists participated in the optimization of patient medication plans from different perspectives,and participated in the use of ribavirin in one case of esophageal cancer with her-pes zoster,where symptoms did not improve;One case of lung cancer accompanied by pulmonary and urinary tract infections,with no improvement in urinary tract symptoms after using cefoperazone sulbactam;One patient with breast cancer had bone marrow suppres-sion and blood flow infection after chemotherapy,and was still feverish after receiving 2 g of cefoperazone sulbactam ivgtt q 12h for 3 days;One case of gastric cancer with heart valve disease,long-term use of warfarin anticoagulation,and gum bleeding after taking capecitabine were reported in four cases.Result In all four cases,the optimization plan proposed by the clinical pharmacist was ad-opted by the doctors.In Case 1,after adjusting ribavirin to acyclovir,the herpes disappeared;Case 2:After switching from cefoperazone sulbactam to piperacillin tazobactam,both lung and urinary symptoms improved significantly;Case 3 changed the usage of cefoperazone sulbactam from q12h to q8h,and the body temperature returned to normal;Case 4 reduced the daily dose of warfarin from 3.75mg to 3.125mg,with no further bleeding in the gums.Conclusion Clinical pharmacists can participate in the optimization of medication plans from the aspects of drug indications,pharmacokinetics,interactions,and infection sites,providing reference for pharmacists to participate in the optimization of drug treatment plans and better ensuring patient medication safety.

Clinical pharmacistOncology DepartmentMedication planOptimization

郭军强、尹锋、熊向乐

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洛阳市中心医院药学部,河南洛阳 471000

临床药师 肿瘤科 用药方案 优化

2024

新疆医学
新疆维吾尔自治区医学会

新疆医学

影响因子:0.385
ISSN:1001-5183
年,卷(期):2024.54(4)
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