Study on the correlation between vitamin D deficiency and diabetic nephropathy
Objective To evaluate the prevalence of vitamin D deficiency in patients with diabetic nephropathy(DKD)of different disease stages and the clinicopathological characteristics of patients with DKD at different stages,and to explore the potential risk fac-tors leading to vitamin D deficiency in patients with DKD and their correlation.Methods In this study,437 patients with different stages of diabetic nephropathy and 100 physical examination personnel were included as healthy control group,and the 25-hydroxyvita-min D(25[OH]D)levels were compared between the two groups.According to the 25[OH]D level classification,the normal group(n=158)and the 25[OH]D level deficiency group(n=379)were analyzed and compared to further explore the independent risk factors of 25[OH]D deficiency.Results The 25[OH]D of diabetic nephropathy patients in all stages was lower than that of healthy control group.The risk of 25[OH]D deficiency was increased by nearly 118%for each increase of BUN 1mmol/L.The risk of 25[OH]D deficiency in-creased by nearly 30%for every 1mmol/L increase in TC.The incidence of 25[OH]D deficiency was positively correlated with hyperlip-idemia,and the incidence of 25[OH]D deficiency was increased by nearly 67%for every 1mmol/L increase of TG.For every 1%in-crease in HbA1c,the risk of developing 25[OH]D deficiency increased by nearly 60%.The incidence of 25[OH]D deficiency increased by 97.2%for every 1mL/min/1.73m2 decrease in eGFR.Conclusion Serum 25[OH]D level may be a powerful predictor of the progres-sion of diabetic nephropathy.
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