Value of the ratio of fibrinogen to red blood cell count in predicting death in patients with coronary heart disease complicated with diabetes after percutaneous coronary intervention
Objective To investigate the value of baseline fibrinogen to red blood cell count ratio(FRR)in predicting death in pa-tientsObjective To investigate the value of baseline fibrinogen to red blood cell count ratio(FRR)in predicting death in patients with coronary heart disease(CHD)complicated with diabetes after percutaneous coronary intervention(PCI).Method This study retrospec-tively included 1027 patients with CHD and diabetes who underwent PCI.Excluding patients with incomplete baseline information and lost follow-up,990 patients were included.The endpoint was all-cause mortality,with a mean follow-up of 35.1±26.2 months.Two groups were divided according to the median FRR:low group(FRR<0.666;N=495)and high group(FRR≥0.666;N=495).Using a mul-tivariate Cox proportional risk model,we assessed the value of FRR predictions over the follow-up period and performed survival analy-ses using Kaplan-Meier methods.Results There were significant differences in gender,smoking,alcohol consumption,PT,DBIL,TP,TBIL,ALB and GLO between the two groups(P<0.05).The incidence of death was significantly higher in the high FRR group than in the low FRR group(P=0.001).In a multivariate Cox proportional hazard model,FRR was an independent predictor of mortality(adjust-ed HR 5.740[1.916-17.196],P=0.002).The receiver operating characteristic curve(ROC)showed that the areas under the curve of FRR,FIB and RBC were 0.658,0.616 and 0.377,respectively.Combined with multivariate Cox proportional risk model and survival curve analysis showed that the survival difference between two groups was statistically significant(log-rank,P<0.05).Conclusion FRR is independently associated with death and can be used as an independent predictor of poor prognosis in patients with CHD com-plicated with diabetes after PCI.
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