495例特应性皮炎患者过敏原检测结果分析
Analysis of allergens detection results of 495 patients with atopic dermatitis
李新媛 1关猛猛 1李婷婷 1刘勇 1石岩 1靳颖 1冯萍萍 1丁媛 1康晓静1
作者信息
- 1. 新疆维吾尔自治区人民医院皮肤性病科;新疆皮肤性病临床医学研究中心;新疆皮肤病研究重点实验室,乌鲁木齐 830001
- 折叠
摘要
目的 分析特应性皮炎(atopic dermatitis,AD)患者血清过敏原检测结果,掌握分布特征.方法 回顾性分析495例AD患者的人口统计学资料及过敏原检测[血清总IgE(tIgE)和特异性IgE(sIgE)]结果进行统计分析.结果 血清tIgE阳性率为80.61%(399/495),男、女患者阳性率之间的差异无统计学意义(82.89%vs 78.02%,χ2=1.872,P=0.171),婴儿组(0-2岁)、儿童组(3-11岁)、青年组(12-18岁)和成年组(>18岁)阳性率之间具有显著差异(77.59%vs 84.76%vs 84.83%vs 67.14%,χ2=12.253,P=0.007).吸入性过敏原中艾蒿阳性率最高21.01%,屋尘次之19.60%;食入性过敏原中鸡蛋阳性率最高36.16%,牛奶次之33.13%,小麦面粉第三22.42%.吸入性过敏原中,除男性交链孢霉的阳性率显著高于女性外,其余吸入性过敏原阳性率男、女之间的差异无统计学意义;男性与女性食入性过敏原阳性率之间的差异均无统计学意义.吸入性过敏原中,除粉尘螨、狗上皮、蟑螂外,其余过敏原在不同年龄组的阳性率均存在显著差异.食入性过敏原中,鸡蛋、牛奶、小麦面粉在不同年龄组的阳性率均存在显著差异.结论 不同年龄组AD患者tIgE阳性率和常见过敏原均存在显著差异,提示在过敏原检测时,应考虑患者的年龄,针对性调整检测项目,同时采取不同的预防措施.
Abstract
Objective To collect the detection results of serum allergens of atopic dermatitis(AD)patients and analyze their distri-bution characteristics.Methods A total of 495 AD patients were retrospectively analyzed for demographic data and allergen detection results[serum total IgE(tIgE)and specific IgE(sIgE)],and statistical analysis was then performed.Results The positive rate of tIgE was 80.61%(399/495),and the difference between male and female patients was not significant(82.89%vs 78.02%,χ2=1.872,P=0.171),and the difference among infant group(0-2 years),children group(3-11 years),youth group(12-18 years)and adults group(>18 years)was significant(77.59%vs 84.76%vs 84.83%vs 67.14%,χ2=12.253,P=0.007).Among inhaled allergens,mugwort had the highest positive rate(21.01%),house dust occupied the second highest(19.60%).Among ingested allergens,egg occupied the highest positive rate(36.16%)followed by milk(33.13%)and wheat flours(22.42%).Among the inhalant allergens,the positive rate of the other inhal-ant allergens was not statistically significant between male and female,except that the male for alternaria was significantly higher than the female,and the positive rate differences of all ingested allergens were not significant.The positive rate differences of inhaled aller-gens among different age groups were significant except for house dust mite,dog hair dander and cockroaches,the positive rate differ-ences of egg,milk and wheat flours in ingested allergens were significant.Conclusions There were significant differences in the posi-tive rates of tIgE and common allergens in AD patients of different age groups,suggesting that the age of patients should be taken into consideration in the detection of allergens,and the detection items should be adjusted accordingly,while different preventive and pro-tective measures should be taken.
关键词
特应性皮炎/过敏原/分布特征/性别/年龄Key words
Atopic dermatitis/Allergens/Distribution characteristics/Sex/Age引用本文复制引用
基金项目
新疆维吾尔自治区自然科学基金(2021D01C201)
出版年
2024
NETL
NSTL
万方数据