To compare the clinical effect of continuous renal replacement therapy with different interventional time on acute renal injury caused by sepsis
Objective To explore the efficacy of continuous renal replacement therapy in the treatment of sepsis induced acute kid-ney injury patients with different interventional therapy timing.Methods From August 2021 to October 2022,80 patients with sepsis induced acute kidney injury receiving continuous renal replacement therapy were randomly divided into 40 patients.The control group received continuous renal replacement therapy in the early stage,and the experimental group received continuous renal replacement therapy in the late stage,and the therapeutic effect was compared.Results Before treatment,PCT,IL-10,IL-6 and TNF-alpha showed no difference between the two groups(P>0.05).After treatment,the levels of inflammatory mediators in both groups decreased,and the relevant indexes in the experimental group were all lower than those in the control group(P<0.05).After treatment,the length of ICU stay and total length of ICU stay in experimental group were shorter than those in control group,P<0.05;Before treatment,the compar-ison of relevant biochemical indicators between the two groups,namely BU,Scr,N%and other indicators,showed no difference,P>0.05.48 hours after treatment,the above indicators of the two groups were improved,and the BUN,Scr,N%levels of the experimental group were lower than those of the control group,P<0.05;The case fatality rate in hospital and 90 days after treatment in experimental group was lower than that in control group(P<0.05).Conclusion In the treatment of acute kidney injury caused by sepsis by continuous renal replacement therapy,early interventional therapy is effective and can reduce mortality and mortality,which is worthy of recom-mendation.
Continuous renal replacement therapyAcute renal injury caused by sepsisDifferent time of interventional therapyBiochemical indicatorsmortality
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