The significance of HS-cTNT,MPO and NT-proBNP in the early diagnosis of acute coronary syndrome
Objective To study the significance of HS-cTNT,MPO and NT-proBNP in the early diagnosis of patients with acute coronary syndrome.Methods 96 patients with ACS who were hospitalized and treated in the outpatient department of cardiology in our hospital from June 2020 to December 2022 were selected as the study group and received routine treatment after admission.The study group included 34 patients with ST-elevation acute myocardial infarction(STEMI),32 patients without STEMI(NSTEMI),and 30 pa-tients with unstable angina pectoris(UAP).35 patients with stable angina pectoris(SAP)were included as control group.The levels of Hs-cTnT,MPO and NT-proBNP of the two groups were recorded and compared,and receiver operating characteristic(ROC)curves were drawn to obtain the cut-off value and the area under the curve(AUC).Results The levels of Hs-cTnT,MPO and NT-proBNP in the study group were significantly higher than those in the control group(P<0.05).The levels of Hs-cTnT,MPO and NT-proBNP in STEMI,NSTEMI and UAP patients were significantly higher than those in the control group(P<0.05);The levels of Hs-cTnT and NT-proBNP in STEMI and NSTEMI patients were significantly higher than those in UAP patients(P<0.05);The levels of Hs-cTnT and NT-proBNP in STEMI patients were significantly higher than those in NSTEMI patients(P<0.05),while there was no significant difference in MPO among STEMI,NSTEMI and UAP patients(P>0.05).Spearman correlation coefficient analysis showed that Hs-cTnT,NT-proBNP and MPO were positively correlated(r=0.71,0.58,P<0.05).Hs-cTnT was positively correlated with NT-proBNP(r=0.79,P<0.05).Using ROC curve analysis,the AUC of the combined diagnosis of Hs-cTnT,NT-proBNP and MPO was significantly higher than that of a single index(P<0.05).At the same time,the sensitivity(93.75%)and specificity(91.67%)of the combination of the three in-dexes were higher than that of the single index Hs-cTnT(70.83%,67.71%),NT-proBNP(78.13%,76.04%)and MPO(83.33%,81.25%),respectively(P<0.05).Conclusion The more serious the condition of ACS patients,the higher the level of Hs-cTnT,NT-proBNP and MPO.The combined diagnosis of Hs-cTnT,NT-proBNP and MPO has higher sensitivity and specificity and has higher di-agnostic value.
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