Study of the effects of repeated rTMS therapy on cognitive function in pediatric and adolescent patients with bipolar depression
Objective To explore the effect of rTMS treatment on cognitive function in children and adolescents with bipolar de-pression.Methods A total of 67 adolescents who were hospitalized and diagnosed with bipolar depression at the department of clinical psychology in our hospital from December 2020 to December 2021 and were willing to accept this research were selected.They were randomly divided into a study group(true stimulation group)and a control group(pseudo stimulation group)based on their single or double numbers,with 39 cases in the study group and 28 cases in the control group.30 children and adolescents who were from healthy people at the physical examination of our hospital and the family members of hospital staff and were willing to cooperate were selected as the healthy group for cognitive function comparison.There was no difference in baseline scores between the study group and the con-trol group,while there was a significant difference in scores between the healthy control group and the other two groups,and the differ-ence was statistically significant(P<0.01).After 2 and 4 weeks of treatment,scores of the MoCA,digit sign replacement test,digit breadth test(forward and backward),and digit line test A of the study group and the control group improved compared to their respec-tive baselines,but there was no statistically significant difference between the two groups(P>0.05).Conclusion This study found that there was a difference in cognitive function between adolescents with bipolar depression and the healthy group,indicating that children and adolescents with bipolar depression have cognitive impairment.rTMS treatment may have an improvement effect on the cognitive function of children and adolescents with bipolar depression,and further research should be needed.
Children and adolescentsBipolar depressionDepressive episoderepeated transcranial magnetic stimulationCogni-tive function
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