Analysis of influencing factors on blood drug concentration in patients with depression treated with sertraline
Objective To analyze the influencing factors of blood drug concentration in patients with depression treated with sertra-line.Method A retrospective analysis was conducted on 106 depression patients admitted to the Second People's Hospital of Zhumadi-an City from March 2020 to August 2022.All patients received continuous treatment with sertraline for 4 weeks.Based on the average blood concentration of the patients over the fourth weekend of treatment,they were divided into a normal sertraline concentration group(n=65)and an abnormal sertraline concentration group(n=41).General information and clinical indicators of the patients were collect-ed,Logistic regression analysis was used to investigate the influencing factors of blood drug concentration in patients with depression af-ter treatment with sertraline.Results Sertraline plasma concentration in patients with normal sertraline plasma concentration and pa-tients with abnormal sertraline plasma concentration had no significant difference in hypertension,diabetes,and serum creatinine(P>0.05).Sertraline plasma concentration in patients with normal sertraline plasma concentration and patients with abnormal sertraline plasma concentration had significant difference in gender,age,liver function,and course of disease(P<0.05).Logistic regression analy-sis showed that gender(OR=4.047),age>25 years old(OR=2.206),abnormal liver function(OR=2.680),and course of disease≥six months(OR=2.768)were all independent factors affecting abnormal sertraline blood concentration(P<0.05).Conclusion Gender,age,course of disease,and liver function are all factors that affect the blood concentration of sertraline in patients with depression.
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