摘要
目的 分析抑郁症患者采用舍曲林治疗血药浓度的影响因素.方法 回顾性分析2020年3月-2022年8月在驻马店市第二人民医院收治的106例抑郁症患者,所有患者均接受舍曲林持续治疗4周,根据患者治疗第4周末的平均血药浓度,将其分为舍曲林血药浓度正常组(n=65)和舍曲林血药浓度异常组(n=41),收集患者的一般资料和临床指标,采用Logistic回归分析抑郁症患者舍曲林治疗后血药浓度的影响因素.结果 舍曲林血药浓度正常组和舍曲林血药浓度异常组患者舍曲林血药浓度比较在高血压、糖尿病、血肌酐方面进行比较差异无统计学意义(P＞0.05),舍曲林血药浓度正常组和舍曲林血药浓度异常组患者舍曲林血药浓度比较在性别、年龄、肝功能和病程方面比较差异有统计学意义(P＜0.05).Logistic回归分析显示,性别为女(OR=4.047)、年龄＞25岁(OR=2.206)、肝功能异常(OR=2.680)、病程≥半年(OR=2.768)均为影响舍曲林血药浓度异常的独立因素(P＜0.05).结论 抑郁症患者性别、年龄、病程和肝功能均为影响其舍曲林血药浓度的影响因素.
Abstract
Objective To analyze the influencing factors of blood drug concentration in patients with depression treated with sertra-line.Method A retrospective analysis was conducted on 106 depression patients admitted to the Second People's Hospital of Zhumadi-an City from March 2020 to August 2022.All patients received continuous treatment with sertraline for 4 weeks.Based on the average blood concentration of the patients over the fourth weekend of treatment,they were divided into a normal sertraline concentration group(n=65)and an abnormal sertraline concentration group(n=41).General information and clinical indicators of the patients were collect-ed,Logistic regression analysis was used to investigate the influencing factors of blood drug concentration in patients with depression af-ter treatment with sertraline.Results Sertraline plasma concentration in patients with normal sertraline plasma concentration and pa-tients with abnormal sertraline plasma concentration had no significant difference in hypertension,diabetes,and serum creatinine(P>0.05).Sertraline plasma concentration in patients with normal sertraline plasma concentration and patients with abnormal sertraline plasma concentration had significant difference in gender,age,liver function,and course of disease(P<0.05).Logistic regression analy-sis showed that gender(OR=4.047),age>25 years old(OR=2.206),abnormal liver function(OR=2.680),and course of disease≥six months(OR=2.768)were all independent factors affecting abnormal sertraline blood concentration(P<0.05).Conclusion Gender,age,course of disease,and liver function are all factors that affect the blood concentration of sertraline in patients with depression.
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