A method for the simultaneous determination of acid red 73 and solvent red 1 in cosmetics by liquid chromatography-tandem mass spectrometry(LC-MS)was developed.The sample was extracted by ultrasonic dispersion of tetrahydrofuran,ammonia or water and sodium chloride,then methanol was added.After ultrasonic centrifugation,the sample was filtered by 0.22 μm filter membrane,and the solution was detected by the electrospray ion source positive ion(ESI+)multi reaction monitoring(MRM)model.The retention time and relative ion pair abundance were used for qualitative analysis,while the external standard method was used for quantitative analysis.The results showed that there was a linear relationship within the range of 2.0-1 000.0 μg/L,with a linear correlation coefficient greater than 0.999.The limits of detection for the two components were 0.034 mg/kg and the limits of quantitation were 0.100 mg/kg.The average recoveries of the two components were 73.1%-112.8%,and the relative standard deviations(RSD)were 1.23%-6.09%(n=6).The method is simple,accurate,highly sensitive,with good recovery and repeatability,and is suitable for the determination of acid red 73 and solvent red 1 in cosmetics.
关键词
化妆品/酸性红73/溶剂红1/液相色谱串联质谱法/外标法
Key words
cosmetics/acid red 73/solvent red 1/liquid chromatography-tandem mass spectrometry(LC-MS)/external standard method
维普
万方数据