Effects and Mechanisms of Compound Essential Oil Sniffing on Wakefulness Maintenance in Sleep Deprived Mice
To investigate the effect and mechanism of nasal inhalation of compound essential oil on awake maintenance in sleep-deprived mice.The results of animal experiments showed that the compound essential oil could not only significantly improve the spontaneous activity of sleep deprivation mice(P<0.01),significantly shorten the sleep time(P<0.01),and maintain awake,but also significantly increase the activities of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)and the levels of dopamine(DA)and glutamic acid(Glu)in the brain(P<0.05,P<0.01),and significantly reduce the level of 5-hydroxytryptamine(5-HT)(P<0.01).The cell results showed that the expression of dopamine transporter(DAT)and serotonin 1A(5-HT1A)protein in the compound essential oil group decreased significantly(P<0.01),and the expression of serotonin transporter(SERT)and vesicular glutamate transporter 1(VGLUT1)protein increased significantly(P<0.05,P<0.01).
compound essential oilsleep deprivationrefresh the mindneurotransmittertransporteracceptor
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