β-烟酰胺单核苷酸霜在经皮护理中的功效机制
Efficacy and Mechanism of β-Nicotinamide Mononucleotide Cream in Percutaneous Care
韦杏芳 1张泽奇 2史雨馨 1罗嘉 1袁燕燕 2林鹏任 2王淑贤 1查梦蕾 1杨平顺2
作者信息
- 1. 南方科技大学生物医学工程系,广东深圳 518055
- 2. 深圳市容大生物科技股份有限公司,广东深圳 518000
- 折叠
摘要
为探究实验室制备β-烟酰胺单核苷酸(NMN)霜的生物功效,借助小鼠光老化模型和自然衰老模型对NMN霜的抗衰老作用及生物安全性进行了评估.结果显示,NMN霜可以通过提高皮肤及血液中抗衰老因子(NAD+和SIRT3)、上调血液中过氧化氢酶(CAT)和超氧化物歧化酶(SOD)的活力及促进皮肤胶原纤维生成达到抗衰老效果;NMN霜治疗组小鼠的血液指标及五脏H&E染色结果相比对照组均无异常,提示NMN霜的生物安全性较高.
Abstract
In order to investigate the biological efficacy of the lab-made β-nicotinamide mononucleotide(NMN)cream,the anti-aging effect and biosafety of the cream were studied by means of mouse photoaging model and natural aging model.The results showed that NMN cream could improve the expression of anti-aging factors(NAD+ and SIRT3)in skin and blood samples,up-regulate the activities of catalase(CAT)and superoxide dismutase(SOD)in blood,promote the formation of skin collagen fibers to achieve the anti-aging effect.In comparation with the control group,no significant difference was noticed in the blood indexes and H&E staining results of the five organs in the NMN cream treatment group,suggesting a highly biological safety of NMN cream.
关键词
β-烟酰胺单核苷酸(NMN)/抗衰老/抗氧化/机制研究/生物安全性Key words
β-nicotinamide mononucleotide(NMN)/anti-aging/anti-oxidation/mechanic study/biosafety引用本文复制引用
基金项目
南科大生医工系-容大生物康美联合实验室项目(K2138Z119)
出版年
2024
NETL
NSTL
维普
万方数据