Efficacy and Mechanism of β-Nicotinamide Mononucleotide Cream in Percutaneous Care
In order to investigate the biological efficacy of the lab-made β-nicotinamide mononucleotide(NMN)cream,the anti-aging effect and biosafety of the cream were studied by means of mouse photoaging model and natural aging model.The results showed that NMN cream could improve the expression of anti-aging factors(NAD+ and SIRT3)in skin and blood samples,up-regulate the activities of catalase(CAT)and superoxide dismutase(SOD)in blood,promote the formation of skin collagen fibers to achieve the anti-aging effect.In comparation with the control group,no significant difference was noticed in the blood indexes and H&E staining results of the five organs in the NMN cream treatment group,suggesting a highly biological safety of NMN cream.
NETL
NSTL
万方数据
维普
