Evaluation of the Bacteriostatic Efficacy and Irritation of 1,2-Octanediol as Moisturizer and Preservative
In order to evaluate inhibitory activity of the moisturizing preservative 1,2-octanediol,the minimum inhibitory concentration(MIC)of 1,2-octanediol was determined by visual inspection and OD600 absorbance value method using the micro broth dilution method,and the results were consistent:the MIC values of Escherichia coli and Candida albicans were 8 mg/mL,and the MIC values for Staphylococcus aureus,Pseudomonas aeruginosa,and Aspergillus niger were 16 mg/mL.With reference to the MIC values,the administered dose was set for multiple times skin stimulation test and eye irritation test.It was determined that 1,2-octanediol was a weak irritant on mammals'skin and eyes.Therefore,1,2-octanediol has good antiseptic and antibacterial effects.It is available to take place of traditional antiseptic as exclusive use or compound with other substances.
cosmetics1,2-octanediolmicro-dilution methodskin irritation testeye irritation test
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万方数据
维普
