Improvement of Transdermal Permeation of Caffeine from Facial Mask Using Freeze-Drying Process with a Layered Coating
In order to improve the transdermal transmission rate of caffeine in facial masks,Hunter method combined with the star composite design-response surface method was used to optimize the key process parameters of layered coating freeze-drying,and the predictive inscriber and design space were applied to determine the acceptable range and optimal values of the process parameters.The coating method and the number of coating layers had significant effects on the transdermal permeation of caffeine,and the coating method was chosen to coat the excipient matrix first,followed by the active ingredient caffeine.The acceptable ranges of the number of coating layers,layer thickness and coating speed were 2-4 layers,0.5-1.2 mm and 1-5 m/min,while the optimal values of the 3 parameters were 3 layers,0.5 mm and 3 m/min,respectively.The caffeine transmittances in 20 min of the three batches of facial masks using optimized process were all more than 10%.Therefore,the optimized layer-coating freeze-drying process could substantially improve the transdermal permeability of caffeine in the masks.
freeze-drying process with layered coatingcaffeinefacial masktransdermal permeationcentral composite design-response surface method
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维普
