分层涂布冷冻干燥工艺改善面膜中的咖啡因经皮透过
Improvement of Transdermal Permeation of Caffeine from Facial Mask Using Freeze-Drying Process with a Layered Coating
李和伟 1魏国志 1许飞飞1
作者信息
- 1. 常州伟博海泰化妆品有限公司,江苏常州 213000
- 折叠
摘要
为了改善面膜中咖啡因的经皮透过率,采用Hunter和星点设计-响应面法优化分层涂布冷冻干燥的关键工艺参数,并应用预测刻画器和设计空间确定工艺参数的可接受范围和最优值.确定涂布方式和涂布层数对咖啡因经皮透过有显著影响,涂布方式选择先涂布辅料基质,再涂布活性成分咖啡因.涂布层数、层厚和涂布速度的可接受范围:2～4 层,0.5～1.2 mm和 1～5 m/min,而 3 个参数的最优值分别为 3 层、0.5 mm和 3 m/min.优化工艺后制备的 3批面膜中咖啡因 20 min透过率均超过 10%.因此,优化后的分层涂布冷冻干燥工艺可大幅度提高面膜中咖啡因的经皮透过率.
Abstract
In order to improve the transdermal transmission rate of caffeine in facial masks,Hunter method combined with the star composite design-response surface method was used to optimize the key process parameters of layered coating freeze-drying,and the predictive inscriber and design space were applied to determine the acceptable range and optimal values of the process parameters.The coating method and the number of coating layers had significant effects on the transdermal permeation of caffeine,and the coating method was chosen to coat the excipient matrix first,followed by the active ingredient caffeine.The acceptable ranges of the number of coating layers,layer thickness and coating speed were 2-4 layers,0.5-1.2 mm and 1-5 m/min,while the optimal values of the 3 parameters were 3 layers,0.5 mm and 3 m/min,respectively.The caffeine transmittances in 20 min of the three batches of facial masks using optimized process were all more than 10%.Therefore,the optimized layer-coating freeze-drying process could substantially improve the transdermal permeability of caffeine in the masks.
关键词
分层涂布冷冻干燥/咖啡因/面膜/经皮渗透/星点设计-响应面法Key words
freeze-drying process with layered coating/caffeine/facial mask/transdermal permeation/central composite design-response surface method引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据