Determination of Hydroxypropyl Tetrahydropyranotriol with Different Configurations in Cosmetics by Ion Chromatography
A method for the determination of hydroxypropyl tetrahydropyrantriol in S and R configurations by ion chromatography was established,and a method for confirming positive samples by liquid chromatography tandem mass spectrometry was established.The method was used to detect cosmetics labelled with hydroxypropyl tetrahydropyrantriol on the market.Hydroxypropyl tetrahydropyrantriol were separated by CarboPac MA1(250 mm×4 mm×1.6 μm)column using 100 mmol/L sodium hydroxide solution as the mobile phase,and qualitative and quantitative analyses were performed by ion chromatography with electrochemical detector.The results showed that there was a good linear relationship between the mass concentration and peak area of S-configuration and R-configuration hydroxypropyl tetrahydropyrantriol(R2>0.999),with a detection limit of 0.001%in mass fraction and a quantitative limit of 0.003%in mass fraction.At high,medium,and low spiking levels,the average recoveries were from 88.09%to 110.1%,with relative standard deviations were in the range of 1.02%-7.62%(n=6).The method has the advantages of simple pretreatment,sensitive and little matrix interference.It is suitable for the simultaneous determination of S and R hydroxypropyl tetrahydropyrantriol in cosmetics.
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万方数据
维普
