Evaluation of Transdermal Penetration Properties and Whitening Efficacy of OLE/GLA Nanoemulsions
Nanoemulsion carriers containing OLE/GLA were prepared by high-pressure homogenization technique,and the transdermal penetration properties and whitening efficacy of OLE/GLA-NEs were investigated.Transdermal permeation studies showed that the nanoemulsions encapsulated OLE/GLA had good skin permeability and skin storage capacity compared with the free component.The results of the cell whitening assay showed that at a concentration of 20 μg/mL of glabridin,the tyrosinase activity inhibition rate of OLE/GLA-NEs reached 78.51%,and the relative content of melanin was only 16.48%compared with free OLE/GLA,and the difference was highly significant(P＜0.01).The results of the 3D melanin skin modeling study showed that OLE/GLA-NEs showed a 6.11%enhancement of L* value and a 12.90%inhibition of melanin content compared with free OLE/GLA,and the difference was significant(P＜0.05).The results of clinical trials showed that after 28 days of using the serum containing 5%(in mass fraction)OLE/GLA-NEs,the melanin content and total area of pigmentation of the skin increased significantly,the L* value and ITA° of the skin increased significantly,the pigmentation became lighter,and the skin became fair and radiant.It is shown that the OLE/GLA-NEs have good whitening effect on the skin and have a good application prospect in the whitening cosmetic market.
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