Synergistic Whitening,Antioxidant and Anti-Inflammatory Activities of Glabridin,Resveratrol and Poldatin Complex
Based on the related phenotype of skin pigmentation,we screened 10 common whitening ingredients and its combinations,and it was found that a composition of polydatin,resveratrol and glabridin showed high efficiency in anti-pigmentation.Even at low concentration of 0.000 1 µmol/L,this composition could significantly inhibit melanogenesis and tyrosinase activity with inhibition rates of 19.47%and 23.7%respectively.Meanwhile,this composition exhibited higher antioxidation and anti-inflammation than single ingredient,which improved DPPH(IC50 0.344 5 mmol/L)and hydroxy(IC50 19.82 mmol/L)scavenging activity,and inhibited the production of inflammatory factors,like NO and TNFα.This composition could also significantly down-regulated the expression of MITF related genes.This study provided a theoretical basis for its application in cosmetics.
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