仿生皮脂脂质体OriginalSL?的开发与皮肤屏障修复效果评估
Development and Evaluation of Biomimetic Sebum Liposomes(OriginalSL?)for Enhanced Skin Barrier Repair
孙静 1卢永杰 1耿林 1刘艳红 1张兵 1张炽坚 1罗莹 2姜乃生2
作者信息
- 1. 花安堂生物科技集团有限公司,广东广州 511400
- 2. 北京科技大学材料科学与工程学院,北京 100083
- 折叠
摘要
旨在通过模拟人体皮肤细胞间脂质的组成和配比,开发一种仿生皮脂脂质体(OriginalSL™).该脂质体通过纳米包裹技术共包裹神经酰胺、胆固醇和白池花(Limnanthes alba)籽油,以模拟皮肤自然分泌的皮脂.结果表明,OriginalSL™为寡层脂质结构,其平均粒径为(170.2±2.3)nm,PDI值为 0.02,包封率为 98.0％,且在体积分数≤2.5％时无明显细胞毒性,细胞安全性良好.在 3D表皮皮肤模型中,相较于单一神经酰胺或白池花籽油脂质体,OriginalSL™具有更好的保湿和修复功效,具有良好的应用价值.
Abstract
This study aims to mimic the composition and ratio of lipids between human skin cells by developing a biomimetic sebum liposome,namely OriginalSL™.This newly developed liposome encapsulated ceramides,cholesterol,and meadowfoam seed oil to mimic natural sebum using the nanoencapsulation technology.The results indicated that OriginalSL™ had an oligolamellar lipid structure,with an average particle size of(170.2±2.3)nm,a PDI value of 0.02,and an encapsulation efficiency of 98.0％.These liposomes showed no obvious cytotoxicity when the concentration less than 2.5％(in volume fraction),indicating good cellular safety.In the 3D epidermal skin model,the OriginalSL™ showed better moisturizing and skin repair efficacy compared to liposomes containing only ceramide or meadowfoam seed oil,which has good potential for barrier repairing of sensitive skin.
关键词
仿生皮脂/皮肤屏障修复/脂质体/神经酰胺/白池花(Limnanthes/alba)籽油Key words
biomimetic sebum/skin barrier repair/liposome/ceramide/meadowfoam(Limnanthes alba)seed oil引用本文复制引用
出版年
2024
NETL
NSTL
万方数据